Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
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Perforalactones D 和 E，两种新的 C-20 苦木素类化合物，具有诱导 Harrisonia perforata (Blanco) Merr 小枝溶酶体生物发生的潜在活性
DOI：
10.1039/d1ob01927a
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发表时间：
2021-10-20
影响因子：
3.2
通讯作者：
Di, Ying-Tong
中科院分区：
文献类型：
--
作者：
Liu, Shuai;Zhang, Cui-Shan;Di, Ying-Tong
本文报道了从中国植物Harrisonia perforata（布兰科）Merr.穿孔内酯E（2）具有不常见的六环1 α，12 α：5 α，13 α-二环-9 β H-苦烷骨架。根据光谱数据和X射线晶体学确定了其结构。化合物1和2通过激活溶酶体基因的转录而显著诱导溶酶体生物合成。
Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1 alpha,12 alpha:5 alpha,13 alpha-dicyclo-9 beta H-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.