The dermal-epidermal junction
The dermal-epidermal junction
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DOI：
10.1016/s0955-0674(97)80118-4
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发表时间：
1997-10-01
影响因子：
7.5
通讯作者：
Christiano, AM
中科院分区：
文献类型：
--
作者：
Burgeson, RE;Christiano, AM
最近对真皮-表皮连接的结构和功能的认识来自两条实验证据的汇合线，即，对皮肤遗传性起泡疾病的研究，其中发现了编码该区域蛋白质的基因的突变，以及在敲除小鼠模型中靶向消融相同的基因。除了这些研究之外，半桥粒/锚定丝复合物的细胞生物学的优雅分析不仅揭示了结构蛋白组分之间功能上重要的相互作用，而且还揭示了某些这些蛋白在介导细胞粘附、迁移和从细胞外基质到角质形成细胞的信号转导中的作用。我们目前对真皮-表皮连接的理解形成了一种新的模型，该模型封装了半桥粒附着结构和interhemidesmosomal附着的性质，这些附着是由皮肤粘附区蛋白质的差异细胞类型特异性表达介导的。
Recent insights into the structure and function of the dermal-epidermal junction have resulted from two converging lines of experimental evidence, namely, the study of inherited blistering disorders of the skin, in which mutations in genes encoding proteins of this region have been discovered, and the targeted ablation of the same genes in knockout mouse models. In addition to these studies, elegant analyses of the cell biology of the hemidesmosome/anchoring filament complex have revealed not only functionally important interactions between structural protein components, but also the role of certain of these proteins in mediating cell adhesion, migration, and signal transduction of messages from the extracellular matrix into the keratinocyte. Our current understanding of the dermal-epidermal junction forms a new model encapsulating the nature both of the hemidesmosomal attachment structures and of the interhemidesmosomal attachments that are mediated by differential cell type specific expression of proteins of the cutaneous adhesion zone.