Ion-selective nano-optodes incorporating quantum dots
Ion-selective nano-optodes incorporating quantum dots
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DOI：
10.1021/ja072522l
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发表时间：
2007-07-11
影响因子：
15
通讯作者：
Clark, Heather A.
中科院分区：
文献类型：
--
作者：
Dubach, J. Matthew;Harjes, Daniel I.;Clark, Heather A.
离子选择量子点(ISQD)能够测量与生理相关的离子(如Na+、K+、Cl-等)。ISQD由量子点、离子选择性聚合物基质和生物相容性涂层组成。ISQD的工作原理是通过聚合物基质选择性地提取离子，这会导致嵌入染料的吸收强度发生变化。这通过直接吸收量子点的荧光发射来衰减量子点的强度。作为这项技术的一个例子，钠选择性ISQD测量1 mm至1 M范围内的钠，比钾选择性高200倍，在10 mm处的分辨率为80微米。
Ion-selective quantum dots (ISQDs) have been produced that are capable of measuring physiologically relevant ions (such as Na+, K+, Cl-, etc.). ISQDs consist of quantum dots, an ion-selective polymer matrix, and a biocompatible coating. ISQDs work by selective ion extraction by the polymer matrix which leads to a change in the absorbance intensity of an embedded dye. This attenuates the intensity of the quantum dot by directly absorbing its fluorescence emission. As an example of this technology, a sodium-selective ISQD measures sodium over the range of 1 mM to 1 M with 200-fold selectivity over potassium and a resolution of 80 mu M at 10 mM.