Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations
Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations
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DOI：
10.1111/ajt.12469
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发表时间：
2013-12-01
影响因子：
8.8
通讯作者：
Shaw, J. A. M.
中科院分区：
文献类型：
--
作者：
Brooks, A. M.;Walker, N.;Shaw, J. A. M.
目的是确定在英国国家资助的综合胰岛移植计划的前3年里，当地分离和运输的制剂是否达到了代谢目标。20名患有c肽阴性1型糖尿病和复发性严重低血糖的胰岛受体患者同意参加这项研究，包括标准化的膳食耐量试验。参与者共接受35次输注（7名受者：单次移植；11名受者：两次移植；2名受者：三次移植）。首次移植后24（13.5-36）个月，移植物功能维持在80%。严重低血糖从移植前的20（7-50）次/患者年减少到移植后的0.3（0-1.6）次/患者年
The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p