Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation from Mechanical Ventilation in Medical Intensive Care Unit Patients
Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation from Mechanical Ventilation in Medical Intensive Care Unit Patients
复制标题
重症监护病房患者脱离机械通气时肢体肌肉和膈肌无力的共存及影响
DOI：
10.1164/rccm.201602-0367oc
复制
发表时间：
2017-01-01
影响因子：
24.7
通讯作者：
Demoule, Alexandre
中科院分区：
文献类型：
--
作者：
Dres, Martin;Dube, Bruno-Pierre;Demoule, Alexandre
基本原理：重症监护室（ICU）和机械通气（MV）获得性肢体肌肉和膈肌功能障碍可能与住院时间更长和预后更差相关。它们是否是同一实体的两个方面或具有不同的患病率和预后影响尚不清楚。目的：量化这两种形式的ICU获得性虚弱的患病率和共存及其对结果的影响。方法：在MV至少24小时后接受首次自主呼吸试验的患者中，膈肌功能障碍的评估使用抽搐气管压力响应于双侧前磁膈神经刺激（压力
Rationale: Intensive care unit (ICU)- and mechanical ventilation (MV)-acquired limb muscle and diaphragm dysfunction may both be associated with longer length of stay and worse outcome. Whether they are two aspects of the same entity or have a different prevalence and prognostic impact remains unclear.Objectives: To quantify the prevalence and coexistence of these two forms of ICU-acquired weakness and their impact on outcome.Methods: In patients undergoing a first spontaneous breathing trial after at least 24 hours of MV, diaphragm dysfunction was evaluated using twitch tracheal pressure in response to bilateral anterior magnetic phrenic nerve stimulation (a pressure