Early evaluation of the response to radiotherapy of patients with squamous cell carcinoma of the head and neck using 18FDG-PET.
Early evaluation of the response to radiotherapy of patients with squamous cell carcinoma of the head and neck using 18FDG-PET.
复制标题
使用 18FDG-PET 早期评估头颈部鳞状细胞癌患者对放疗的反应。
DOI：
10.1016/j.oraloncology.2004.10.005
复制
发表时间：
2005
期刊：
影响因子：
4.8
通讯作者：
B. Lee
中科院分区：
文献类型：
--
作者：
S. Nam;Sang‐wook Lee;K. Im;Jae;S. Kim;S. Choi;J. Ryu;D. Moon;Seung;B. Yi;Jong Hoon Kim;S. Ahn;S. Shin;Sung;E. Choi;B. Lee
目的是评估 2-[F-18]氟-2-脱氧-d-葡萄糖 (FDG) 正电子发射断层扫描 (PET) 在头颈鳞状细胞癌 (SCCHN) 患者对根治性放疗 (RT) 反应的早期鉴别中的功效。对 2001 年 8 月至 2002 年 9 月期间在牙山医疗中心接受非播散性 SCCHN 放疗前后接受 FDG-PET 扫描的 24 名患者进行了前瞻性评估。初次 FDG-PET 扫描在 RT 前 1 个月内进行，后续 FDG-PET 扫描在 RT 完成后 1 个月进行。通过标准摄取值（SUV）分析 FDG-PET 图像。所有患者均随访6个月以上。治疗前 SUV 范围为 3.4 至 14.0（中位数为 6.0），而治疗后 SUV 范围为地面至 7.7（中位数为 2.0）。在评估这些 SCCHN 患者的残留肿瘤时，FDG-PET 的总体敏感性为 100%，而其总体特异性为 87%。 FDG-PET 可有效评估 SCCHN 患者对放射的反应。 RT 完成后 1 个月进行后续 FDG-PET 扫描对于评估放射反应来说并不算太快。
The aim was to evaluate the efficacy of positron emission tomography (PET) with 2-[F-18]fluoro-2-deoxy-d-glucose (FDG) in early discrimination of response to definitive radiotherapy (RT) in patients with squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients who underwent FDG-PET scans before and after radiotherapy for nondisseminated SCCHN at the Asan Medical Center between August 2001 and September 2002 were prospectively evaluated. Initial FDG-PET scans were performed within 1month before RT, and follow-up FDG-PET scans were performed 1month after completion of RT. FDG-PET images were analyzed by standard uptake value (SUV). All patients were followed for more than 6months. Pretreatment SUV ranged from 3.4 to 14.0 (median, 6.0), while posttreatment SUV ranged from ground level to 7.7 (median, 2.0). In evaluating residual tumors in these SCCHN patients, the overall sensitivity of FDG-PET was 100%, while its overall specificity was 87%. FDG-PET is effective in evaluating the response to radiation in patients with SCCHN. Timing the follow-up FDG-PET scan 1month after completion of RT was not too rapid for evaluating the response to radiation.
DOI：
--
发表时间：
1981
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Larson,SM;Weiden,PL;Grunbaum,Z;Kaplan,HG;Rasey,JS;Graham,MM;Sale,GE;Harp,GD;Williams,DL
通讯作者：
Williams,DL