Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.
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DOI：
10.1016/j.stem.2023.04.011
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发表时间：
2023-05-04
期刊：
影响因子：
23.9
通讯作者：
Chen, Shuibing
中科院分区：
文献类型：
--
作者：
Vandana, J. Jeya;Manrique, Cassandra;Lacko, Lauretta A.;Chen, Shuibing
人类多能干细胞（hPSC）和三维类器官开创了疾病建模和药物发现的新时代。在过去的十年中，在从hPSC衍生功能性类器官方面取得了重大进展，其已被应用于概括疾病表型。此外，这些进展扩展了hPSC和类器官在药物筛选和临床试验安全性评估中的应用。本文综述了利用hPSC衍生的类器官进行相关高通量、高含量筛选和药物评价的成就和挑战。这些研究极大地增强了我们对精准医学的知识和工具箱。Vandana及其同事对使用人类多能干细胞（hPSC）和类器官进行药物筛选和临床试验安全性评估的最新进展进行了全面综述。他们还讨论了与使用hPSC衍生的类器官进行相关的高通量，高内容筛选和药物评估相关的挑战和进展。
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a new era for disease modeling and drug discovery. Over the past decade, significant progress has been in deriving functional organoids from hPSCs, which have been applied to recapitulate disease phenotypes. In addition, these advancements have extended the application of hPSCs and organoids for drug screening and clinical-trial safety evaluations. This review provides an overview of the achievements and challenges in using hPSC-derived organoids to conduct relevant high-throughput, high-contentscreens and drug evaluation. These studies have greatly enhanced our knowledge and toolbox for precision medicine. Vandana and colleagues present a comprehensive review of the recent progress in using human pluripotent stem cells (hPSCs) and organoids for drug screening and clinical-trial safety evaluations. They also discuss the challenges and advancement associated with using hPSC-derived organoids for relevant high-throughput, high-content screens and drug evaluations.
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人类肺发育和疾病的三维模型来自多能干细胞。
影响因子：
21.3
作者：
Chen YW;Huang SX;de Carvalho ALRT;Ho SH;Islam MN;Volpi S;Notarangelo LD;Ciancanelli M;Casanova JL;Bhattacharya J;Liang AF;Palermo LM;Porotto M;Moscona A;Snoeck HW
通讯作者：
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影响因子：
16.6
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通讯作者：
Peltz G
影响因子：
23.9
作者：
Czerniecki SM;Cruz NM;Harder JL;Menon R;Annis J;Otto EA;Gulieva RE;Islas LV;Kim YK;Tran LM;Martins TJ;Pippin JW;Fu H;Kretzler M;Shankland SJ;Himmelfarb J;Moon RT;Paragas N;Freedman BS
通讯作者：
Freedman BS
影响因子：
64.5
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通讯作者：
Roska B
影响因子：
16.6
作者：
Hale, Lorna J.;Howden, Sara E.;Little, Melissa H.
通讯作者：
Little, Melissa H.