Sarcopenia Prevalence Using Different Definitions in Older Community-Dwelling Canadians
Sarcopenia Prevalence Using Different Definitions in Older Community-Dwelling Canadians
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DOI：
10.1007/s12603-020-1427-z
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发表时间：
2020-06-24
影响因子：
5.8
通讯作者：
Prado, C. M.
中科院分区：
文献类型：
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作者：
Purcell, S. A.;Mackenzie, M.;Prado, C. M.
肌少症是一种影响全球数百万人的衰弱性疾病，有不同的定义标准。本研究的目的是使用三个国际公认的标准来确定加拿大老年人肌肉减少症的患病率。设计观察性队列研究。背景和参与者纳入加拿大老龄化纵向研究中年龄为65岁的12592名受试者[男性6,314人（50.1%），女性6,278人（49.9%）]。测量方法：通过双x线吸收测量法采集阑尾瘦质量（ALM; kg）和阑尾瘦质量指数（ALM kg/身高，m(2)）。采用4米步速测试评估体能表现，采用手测力法测量肌肉力量。肌少症的定义是根据国际肌少症工作组（IWGS）、美国国立卫生研究院（FNIH）肌少症项目基金会和修订后的欧洲老年人肌少症工作组（EWGSOP）提出的标准。阳性和阴性百分比一致，科恩的kappa （kappa）描述了肌少症定义之间的一致。结果在评价标准中，步态速度= 95%。结论加拿大老年人肌少症患病率相对较低，目前的定义在诊断个体肌少症时一致性较差。
Objectives Sarcopenia is a debilitating condition affecting millions of individuals worldwide and is defined with different criteria. The objective of this study was to determine the prevalence of sarcopenia in older Canadians using three internationally accepted criteria. Design Observational cohort study. Settings and participants Data from 12,592 subjects [6,314 males (50.1%), 6,278 females (49.9%)] >= 65 years old in the Canadian Longitudinal Study on Aging were included. Measurements: Appendicular lean mass (ALM; kg) and appendicular lean mass index (ALM kg/height in m(2)) were collected from dual X-ray absorptiometry measurements. Physical performance was assessed using the 4-m gait speed test, and muscle strength was measured by hand dynamometry. Sarcopenia was defined according to criteria put forth by the International Working Group on Sarcopenia (IWGS), Foundation for the National Institutes of Health (FNIH) Sarcopenia Project, and revised European Working Group on Sarcopenia in Older People (EWGSOP). Positive and negative percent agreements and Cohen's kappa (kappa) described the agreement among sarcopenia definitions. Results Among the evaluated criteria, gait speed = 95%. Conclusion Sarcopenia prevalence was relatively low in older Canadian adults and current definitions had poor agreement in diagnosing individuals as sarcopenic.