Significant CMAP decrement by repetitive nerve stimulation is more frequent in median than ulnar nerves of patients with amyotrophic lateral sclerosis
Significant CMAP decrement by repetitive nerve stimulation is more frequent in median than ulnar nerves of patients with amyotrophic lateral sclerosis
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DOI：
10.1002/mus.22301
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发表时间：
2012-03-01
期刊：
影响因子：
3.4
通讯作者：
Uchino, Makoto
中科院分区：
文献类型：
--
作者：
Yamashita, Satoshi;Sakaguchi, Hideya;Uchino, Makoto
简介：肌萎缩侧索硬化症（ALS）患者的复合肌肉动作电位（CMAP）在重复神经刺激（RNS）时振幅显著降低，肌萎缩优先影响鱼际肌（APB）而非小鱼际肌（ADM）。研究方法：我们在32例ALS患者的APB和ADM肌肉中进行了RNS研究，以确定RNS对正中神经和尺神经的影响是否不同。结果如下：RNS的递减反应在APB大于ADM。减少CMAP振幅与CMAP递减呈负相关，但在尺神经。结论：正中神经中更大的CMAP递减可归因于ALS的病理生理学中APB的优先参与或两种肌肉/神经的生物学中的一些潜在差异。进一步的研究将使我们更好地了解ALS的病理生理学。肌肉神经，2012
Introduction: Several studies have shown a significant amplitude decrement in compound muscle action potentials (CMAPs) on repetitive nerve stimulation (RNS) of muscles involved in amyotrophic lateral sclerosis (ALS).In ALS, muscle wasting preferentially affects the thenar muscles (APB) rather than the hypothenar muscles (ADM). Methods: We performed RNS studies in the APB and ADM muscles of 32 ALS patients to determine whether the effect of RNS differs between the median and ulnar nerves. Results: The decremental responses to RNS were greater in the APB than in the ADM. Reduced CMAP amplitude was negatively correlated with CMAP decrement in median but not in ulnar nerves. Conclusions: The greater CMAP decrement in median nerve is attributable to preferential involvement of the APB in the pathophysiology of ALS or some underlying difference in the biology of the two muscles/nerves. Further investigations will better our understanding of the pathophysiology of ALS. Muscle Nerve, 2012