Occupational sedentary behavior and prediction of proteinuria in young to middle-aged adults: a retrospective cohort study
Occupational sedentary behavior and prediction of proteinuria in young to middle-aged adults: a retrospective cohort study
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DOI：
10.1007/s40620-020-00826-w
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发表时间：
2020-08-27
影响因子：
3.4
通讯作者：
Moriyama, Toshiki
中科院分区：
文献类型：
--
作者：
Fujii, Yoshiyuki;Yamamoto, Ryohei;Moriyama, Toshiki
背景虽然久坐行为是心脏代谢疾病和死亡率的危险因素，但关于职业久坐行为对慢性肾脏病（CKD）的临床影响的信息很少。方法本回顾性队列研究包括日本国立大学的10，212名工作人员，他们在2006年4月至2013年3月期间进行了年度健康检查。关注的主要暴露是基线访视时自我报告的职业久坐行为。结果是蛋白尿的发生率，定义为试纸尿蛋白1 +或更多。使用调整临床相关因素的考克斯比例风险模型评估久坐工人与蛋白尿发生率之间的关系，包括看电视时间，主要的家庭久坐行为。结果在中位4.8年（四分位距2.1-7.9）的观察期内，在597例（12.0%）男性和697例（13.3%）女性中观察到蛋白尿的发生。在男性中，久坐的工人被认为是蛋白尿的重要预测因素（非久坐和久坐工作者的多变量校正风险比：1.00 [参考]和1.35 [1.11-1.63]），沿着较长的电视观看时间（< 30分钟、30-60分钟、1-2小时、2-3小时和> 3小时/天：1.15 [0.93-1.42]、1.00 [参考]、1.24 [1.00-1.53]、1.41 [1.03-1.93]和1.77 [1.13-2.76]），而不是每日运动时间。在女性中，久坐不动的工人和看电视的时间与蛋白尿的发生率无关。结论男性久坐工人是蛋白尿的高危人群。职业久坐行为可能是一个潜在的可修改的目标，以预防CKD。
Background Although sedentary behavior is a risk factor of cardiometabolic diseases and mortality, little information is available about a clinical impact of occupational sedentary behavior on chronic kidney disease (CKD). Methods The present retrospective cohort study included 10,212 workers of a national university in Japan who underwent annual health checkups between April 2006 and March 2013. Main exposure of interest was self-reported occupational sedentary behavior at the baseline visit. The outcome was the incidence of proteinuria defined as dipstick urinary protein of 1 + or more. The association between sedentary workers and the incidence of proteinuria was assessed using Cox proportional hazards models adjusting for clinically relevant factors, including television viewing time, the major home sedentary behavior. Results During median 4.8 years (interquartile range 2.1-7.9) of the observational period, the incidence of proteinuria was observed in 597 (12.0%) males and 697 (13.3%) females. In males, sedentary workers were identified as a significant predictor of proteinuria (multivariable-adjusted hazard ratio of non-sedentary and sedentary workers: 1.00 [reference] and 1.35 [1.11-1.63]), along with longer television viewing time (< 30 min, 30-60 min, 1-2 h, 2-3 h, and > 3 h/day: 1.15 [0.93-1.42], 1.00 [reference], 1.24 [1.00-1.53], 1.41 [1.03-1.93], and 1.77 [1.13-2.76]), whereas not daily exercise time. In females, neither sedentary workers nor television viewing time was associated with the incidence of proteinuria. Conclusions In conclusion, male sedentary workers were at high risk of proteinuria. Occupational sedentary behavior may be a potentially modifiable target for the prevention of CKD.