Higher Serum Free Testosterone Concentration in Older Women Is Associated with Greater Bone Mineral Density, Lean Body Mass, and Total Fat Mass: The Cardiovascular Health Study
Higher Serum Free Testosterone Concentration in Older Women Is Associated with Greater Bone Mineral Density, Lean Body Mass, and Total Fat Mass: The Cardiovascular Health Study
复制标题
DOI：
10.1210/jc.2010-0926
复制
发表时间：
2011-04-01
影响因子：
5.8
通讯作者：
Cappola, Anne R.
中科院分区：
文献类型：
--
作者：
Rariy, Chevon M.;Ratcliffe, Sarah J.;Cappola, Anne R.
内容：内源性睾酮（T）在老年妇女中的生理重要性知之甚少。目的：本研究的目的是确定老年妇女中较高的总T和游离T水平与骨矿物质密度（BMD）、瘦体重和脂肪量之间的关系。设计：在232名年龄在67-94岁的社区居民妇女中，使用敏感的测定方法测量总T和游离T，这些妇女参加了心血管健康研究，并接受了双能量x-射线治疗。射线吸收扫描。进行横断面分析，以检查总T和游离T与BMD和身体成分之间的关系。在校正模型中，总T与腰椎BMD直接相关（P = 0.04）和髋关节（P = 0.001），但不是身体成分的结果，在所有妇女，并排除雌激素使用者和调整雌二醇后，（P分别为0.04和0.01）。游离T与髋部BMD、瘦体重和体脂呈正相关（P < 0.05），游离T范围最高端和最低端的女性之间的每个结果差异超过10%，排除雌激素使用者并调整Esteriol.Conclusions后衰减：在老年女性雌二醇水平较低的情况下，循环T水平与骨密度相关。游离T水平较高的女性有更大的瘦体重，与T的合成代谢作用一致，并且与男性相比，脂肪量更大。需要进行机制研究，以确定在该人群中T、骨和身体组成之间是否存在因果关系，以及任何T效应与雌激素无关的程度。（临床内分泌代谢杂志96：989-996，2011）
Context: The physiological importance of endogenous testosterone (T) in older women is poorly understood.Objective: The aim of the study was to determine the association of higher total and free T levels with bone mineral density (BMD), lean body mass, and fat mass in elderly women.Design: Total and free T were measured using sensitive assays in 232 community-dwelling women aged 67-94 yr who were enrolled in the Cardiovascular Health Study and had dual-energy x-ray absorptiometry scans. Cross-sectional analyses were performed to examine associations between total and free T and BMD and body composition.Results: In adjusted models, total T was directly associated with BMD at the lumbar spine (P = 0.04) and hip (P = 0.001), but not body composition outcomes, in all women, and after excluding estrogen users and adjusting for estradiol (P = 0.04 and 0.01, respectively). Free T was positively related to hip BMD, lean body mass, and body fat (all P < 0.05), with more than 10% differences in each outcome between women at the highest and lowest ends of the free T range, with attenuation after excluding estrogen users and adjusting for estradiol.Conclusions: In the setting of the low estradiol levels found in older women, circulating T levels were associated with bone density. Women with higher free T levels had greater lean body mass, consistent with the anabolic effect of T, and, in contrast to men, greater fat mass. Mechanistic studies are required to determine whether a causal relationship exists between T, bone, and body composition in this population and the degree to which any T effects are estrogen-independent. (J Clin Endocrinol Metab 96: 989-996, 2011)