Modulation of Frequency Preference in Heterogeneous Populations of Theta-resonant Neurons
Modulation of Frequency Preference in Heterogeneous Populations of Theta-resonant Neurons
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DOI：
10.1016/j.neuroscience.2019.10.054
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发表时间：
2020-02-01
期刊：
影响因子：
3.3
通讯作者：
Sanhueza, Magdalena
中科院分区：
文献类型：
--
作者：
Vera, Jorge;Pereira, Ulises;Sanhueza, Magdalena
来自几个大脑区域的神经元在θ频率范围（4-12 Hz）内共振，在优选的“共振”频率（f（R））下对振荡电流显示出更高的电压响应。阈下共振可以影响尖峰信号，并有助于在伴随多个认知过程的网络振荡活动期间选择性地夹带神经元。来自不同区域的神经元在特定的θ子范围内显示共振，表明功能专业化。需要进一步的实验工作来表征这种多样性，并探索如何动态调制频率偏好。理论研究表明，谐振的微调以复杂的方式取决于各种内在因素和输入属性，但它们的具体影响很难在细胞中剖析。我们进行切片电生理，动态钳和建模，以评估大鼠内嗅星状神经元，海马CA 1区锥体神经元和杏仁核皮质神经元，共享超极化激活电流（I-H）依赖的共振机制的差分频率偏好。我们发现不同类型的θ共振神经元之间以及每个特定组中存在异质共振特性。在所有研究的神经元中，f（R）与有效输入电阻（R-in）呈负相关，这是一个依赖于被动和主动膜特征的可测量变量。我们表明，可以通过模拟自然发生的过程的操作来调节共振，如并入虚拟恒定电导或细胞去极化，以保持f（R）-R-in关系的方式。频率选择性的调制通过改变尖峰频率和定时来影响放电，这可能影响主动网络中的神经元通信。(C)2019年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Neurons from several brain regions resonate in the theta frequency range (4-12 Hz), displaying a higher voltage response to oscillatory currents at a preferred 'resonant' frequency (f(R)). Subthreshold resonance could influence spiking and contribute to the selective entrainment of neurons during the network oscillatory activity that accompanies several cognitive processes. Neurons from different regions display resonance in specific theta subranges, suggesting a functional specialization. Further experimental work is needed to characterize this diversity and explore how frequency preference could be dynamically modulated. Theoretical studies have shown that the fine-tuning of resonance depends in a complex way on a variety of intrinsic factors and input properties, but their specific influence is difficult to dissect in cells. We performed slice electrophysiology, dynamic clamping and modelling to assess the differential frequency preference of rat entorhinal stellate neurons, hippocampal CA1 pyramidal neurons and cortical amygdala neurons, which share a hyperpolarization-activated current (I-h)-dependent resonance mechanism. We found heterogeneous resonance properties among the different types of theta-resonant neurons, as well as in each specific group. In all the neurons studied, f(R) inversely correlated with the effective input resistance (R-in), a measurable variable that depends on passive and active membrane features. We showed that resonance can be adjusted by manipulations mimicking naturally occurring processes, as the incorporation of a virtual constant conductance or cell depolarization, in a way that preserves the f(R)-R-in relationship. The modulation of frequency selectivity influences firing by shifting spike frequency and timing, which could influence neuronal communication in an active network. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.