Living polymerization of α-amino acid N-carboxyanhydrides (NCA) upon decreasing the reaction temperature
Living polymerization of α-amino acid N-carboxyanhydrides (NCA) upon decreasing the reaction temperature
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DOI：
10.1002/marc.200400111
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发表时间：
2004-07-05
影响因子：
4.6
通讯作者：
Schué, F
中科院分区：
文献类型：
--
作者：
Vayaboury, W;Giani, O;Schué, F
采用非水毛细管电泳技术研究了N，N-二甲甲酰胺中N- ε -三氟乙酰赖氨酸-羧基氢化物的正己胺引发聚合反应。得到了分子量分布较宽的多肽，在室温下进行聚合时，副反应得到了明确的鉴定。证明了0℃下活性聚合的可能性。
The n-hexylamine-initiated polymerization of N-epsilon-trifluoroacetyl-L-lysine N-carboxyanhydride in N,N-dimethyformamide was studied by nonaqueous capillary electrophoresis. A polypeptide with a broad molecular weight distribution was obtained and side reactions were clearly identified for polymerization at room temperature. The possibility of living polymerization at 0degrees C demonstrated.