Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination
Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination
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DOI：
10.1021/jacs.9b13684
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发表时间：
2020-02-26
影响因子：
15
通讯作者：
Shi, Hang
中科院分区：
文献类型：
--
作者：
Kang, Qi-Kai;Lin, Yunzhi;Shi, Hang
我们开发了Ru/半可溶配体催化的芳基氟化物亲核取代（SNAr）作为限制试剂。在不使用过量芳烃的情况下，SNAr胺化中富电子芳烃和中性芳烃的参与证明了显著的配体增强。初步的机理研究表明，亲核取代发生在Ru催化剂和底物的eta(6)-配合物上，半可溶配体促进了产物与金属中心的解离。
We developed a Ru/hemilabile-ligand-catalyzed nucleophilic aromatic substitution (SNAr) of aryl fluorides as the limiting reagents. Significant ligand enhancement was demonstrated by the engagement of both electron-rich and neutral arenes in the SNAr amination without using excess arenes. Preliminary mechanistic studies revealed that the nucleophilic substitution proceeds on a eta(6)-complex of the Ru catalyst and the substrate, and the hemilabile ligand facilitates dissociation of products from the metal center.