Plasma des-acyl and acyl ghrelin in patients with eating disorders
Plasma des-acyl and acyl ghrelin in patients with eating disorders
复制标题
饮食失调患者的血浆去酰基和酰基生长素释放肽
DOI：
10.1007/bf03327494
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
K. Kangawa
中科院分区：
文献类型：
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作者：
T. Uehara;I. Omori;K. Nakamura;M. Suda;Y. Hosoda;T. Minegishi;M. Mikuni;K. Kangawa
最近发现的一种多肽，Ghrelin，可以增加人类的食欲和能量储备。以前的报告显示，进食障碍(ED)患者的血浆水平较高，并与身体质量指数(BMI)相关。这项研究通过测量血浆Ghrelin的活性(N-RIA)和总(C-RIA)水平来检验这些发现。对11例勃起功能障碍患者和5例对照女性进行多目标症状评估。结果显示C-RIA在两组间有显著差异。BMI与Ghrelin无相关性，但与ED组和对照组的N-RIA/C-RIA(NC)比值呈负相关。NC比率也倾向于与自我评级分数相关。NC比率可能与ED患者Ghrelin分泌或清除的特异性有关。进一步的基础和临床研究是必要的。
A recently recognized peptide, ghrelin, increases appetite and energy retention in human. Previous reports have shown higher plasma level in eating disorder (ED) patients and correlations with body mass index (BMI). This study examined these findings by measuring active (N-RIA) and total (C-RIA) levels of plasma ghrelin. Multipurpose assessments of symptoms were conducted for 11 ED patients and 5 control females. Results revealed significant differences of C-RIA between the groups. The BMI did not correlate with ghrelin, but demonstrated reversal correlation with the ratio of N-RIA and C-RIA (NC ratio) according to the ED or control group. The NC ratio also tended to be associated with a self-rating score. The NC ratio might be related to specific characteristics of ghrelin secretion or clearance in ED patients. Further basic and clinical investigations are necessary.