CIRCULATING ANTI-TUBULAR BASEMENT-MEMBRANE ANTIBODY IN A VARIETY OF HUMAN RENAL DISEASES - DETECTION AND SIGNIFICANCE
CIRCULATING ANTI-TUBULAR BASEMENT-MEMBRANE ANTIBODY IN A VARIETY OF HUMAN RENAL DISEASES - DETECTION AND SIGNIFICANCE
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DOI：
10.1159/000181943
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发表时间：
1980-01-01
期刊：
影响因子：
2.5
通讯作者：
CATTRAN, DC
中科院分区：
文献类型：
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作者：
CATTRAN, DC
用血凝法(HA)和间接免疫荧光法(IIF)检测99例肾小管基底膜(TBM)循环抗体。11例患者有抗TBM抗体阳性。其中6例肾小球基底膜(GBM)抗体阳性。另5例仅有抗TBM抗体，具有独特的自然病史和治疗反应，提示该抗体在其发病机制中起重要作用。在终末器官损伤中看到的变化可能表明其他因素，可能是遗传因素，参与了病理生理。
Serum specimens from 99 selected renal patients were examined over a 3 yr period by both a hemagglutination technique (HA) and an indirect immunofluorescent (IIF) method for the presence of circulating antibody against tubular basement membrane (TBM). Eleven patients were found with anti-TBM antibodies. Six of them also had antibody against glomerular basement membrane (GBM). The other 5 with anti-TBM antibody alone, had a unique natural history and response to therapy which suggested that the antibody was important in the pathogenesis of their disease. The variation seen in end organ damage may indicate that other factors, possibly genetic, are involved in the pathophysiology.