FUNCTIONAL-ROLE OF TYPE-I AND TYPE-II INTERFERONS IN ANTIVIRAL DEFENSE
FUNCTIONAL-ROLE OF TYPE-I AND TYPE-II INTERFERONS IN ANTIVIRAL DEFENSE
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DOI：
10.1126/science.8009221
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发表时间：
1994-06-24
期刊：
影响因子：
56.9
通讯作者：
AGUET, M
中科院分区：
文献类型：
--
作者：
MULLER, U;STEINHOFF, U;AGUET, M
缺乏I型干扰素（IFN）受体的已知亚基的小鼠对I型IFN完全无反应，这表明该受体链对I型IFN介导的信号转导是必需的。这些小鼠没有表现出明显的异常，但无法科普病毒感染，尽管其他免疫反应正常。缺乏I型或II型IFN受体的小鼠的比较表明，至少在对某些病毒的反应中，这两种IFN系统对于抗病毒防御是必不可少的，并且在功能上是非冗余的。
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.