The potential of GHK as an anti-aging peptide.
The potential of GHK as an anti-aging peptide.
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DOI：
10.31491/apt.2020.03.014
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发表时间：
2020-03-27
期刊：
影响因子：
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通讯作者：
Ladiges W
中科院分区：
文献类型：
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作者：
Dou Y;Lee A;Zhu L;Morton J;Ladiges W
GHK(甘氨酰-L-组氨酸-L-赖氨酸)是一种天然存在于人血清中的多肽，20岁时平均水平为200 ng/ml，但到60岁时下降到平均80 ng/ml。该分子与铜有很高的亲和力，形成了络合物GHK-铜。该多肽及其铜(II)螯合物具有抗炎和组织重塑的特性。体外和体内研究表明，GHK-Cu具有促进皮肤重塑、创面愈合和再生的作用，并具有显著的抗氧化和抗炎作用。此外，初步观察表明，GHK可以通过靶向抗炎和表观遗传途径部分逆转衰老小鼠的认知障碍。目前提出的证据为在临床前和临床衰老研究中进一步研究这种自然产生的多肽提供了理论基础。
GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing and regeneration, and has prominent antioxidant and anti-inflammatory effects in in vitro and in vivo studies. In addition, preliminary observations suggest GHK can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways. The evidence as presented provides the rationale to further investigate this naturally occurring peptide in preclinical and clinical aging studies.