INACTIVATION PROPERTIES OF VOLTAGE-GATED K+ CHANNELS ALTERED BY PRESENCE OF BETA-SUBUNIT
INACTIVATION PROPERTIES OF VOLTAGE-GATED K+ CHANNELS ALTERED BY PRESENCE OF BETA-SUBUNIT
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DOI：
10.1038/369289a0
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发表时间：
1994-05-26
期刊：
影响因子：
64.8
通讯作者：
PONGS, O
中科院分区：
文献类型：
--
作者：
RETTIG, J;HEINEMANN, SH;PONGS, O
大鼠脑内电压门控K（v）1型钾通道的结构和功能多样性通过两种不同类型亚基的结合而增强，这两种亚基是膜结合的、孔形成的α亚基和外周β亚基。我们克隆了一个β亚基（K-v β 1），它在大鼠神经系统中特异性表达。在体外表达系统中，K-v β 1与α亚基的结合可使非失活K（v）1通道（延迟整流器）快速A型失活。该作用由K-v β 1氨基末端的失活球结构域介导。
Structural and functional diversity of voltage-gated K(v)1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, pore-forming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (K-v beta 1) that is specifically expressed in the rat nervous system. Association of K-v beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating K(v)1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the K-v beta 1 amino terminus.