Fluorescent sensor responsive to local viscosity and its application to the imaging of liquid-ordered domain in lipid membranes
Fluorescent sensor responsive to local viscosity and its application to the imaging of liquid-ordered domain in lipid membranes
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DOI：
10.1016/j.colsurfb.2008.08.004
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发表时间：
2008-11-15
影响因子：
5.8
通讯作者：
Kikuchi, Jun-ichi
中科院分区：
文献类型：
--
作者：
Yasuhara, Kazuma;Sasaki, Yoshihiro;Kikuchi, Jun-ichi
设计并合成了一种对脂质双层膜局部粘度敏感的新型荧光传感器。传感器改变其荧光强度，反映其周围介质的局部粘度。荧光测量表明该传感器能够区分脂质双层的不同相状态。此外，该传感器还通过简单的荧光技术在微粘度方面可视化了巨型囊泡上的液体有序微域。 (C) 2008 Elsevier B.V. 保留所有权利。
A novel fluorescent sensor responsive to local viscosity in the lipid bilayer membranes was designed and synthesized. The sensor changes its fluorescence intensity reflecting the local viscosity of its surrounding medium. The fluorescence measurement showed that the sensor is capable of discriminating between different phase states of lipid bilayer. In addition, the sensor visualized liquid-ordered microdomains on giant vesicles in terms of the microviscosity with a simple fluorescence technique. (C) 2008 Elsevier B.V. All rights reserved.