Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.
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DOI：
10.1158/0008-5472.can-12-4561
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发表时间：
2013-04-15
期刊：
影响因子：
11.2
通讯作者：
Blakey DC
中科院分区：
文献类型：
--
作者：
Prabhakar U;Maeda H;Jain RK;Sevick-Muraca EM;Zamboni W;Farokhzad OC;Barry ST;Gabizon A;Grodzinski P;Blakey DC
肿瘤血管的渗透性增强允许大分子进入肿瘤间质空间，而被抑制的淋巴滤过使它们留在那里。这一现象-EPR一直是纳米技术平台向肿瘤输送药物的基础。然而，由于EPR效应在不同肿瘤中的异质性，以及患者关于这一机制与促进药物积累有关的有效性的实验数据有限，使用这种方法开发有效药物的进展一直受到阻碍。这份报告总结了研讨会对EPR效应的关键问题的讨论，以及需要解决的主要差距，以有效地推进基于纳米颗粒的药物输送。
Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, while the suppressed lymphatic filtration allows them to stay there. This phenomenon - EPR has been the basis of nanotechnology platforms to deliver drugs to tumors. However, progress in developing effective drugs using this approach has been hampered by heterogeneity of EPR effect in different tumors and limited experimental data from patients on effectiveness of this mechanism as related to enhanced drug accumulation. This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery.