Effects of Sleep Deprivation on Measures of the Febrile Reaction and the Recovery of Somatovisceral Functions and Sleep in Endotoxemia
Effects of Sleep Deprivation on Measures of the Febrile Reaction and the Recovery of Somatovisceral Functions and Sleep in Endotoxemia
复制标题
睡眠剥夺对内毒素血症发热反应、躯体内脏功能恢复和睡眠的影响
DOI：
10.1007/s11055-010-9268-6
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发表时间：
2010
影响因子：
--
通讯作者：
I. Ekimova
中科院分区：
文献类型：
--
作者：
K. V. Lapshina;I. Ekimova
采用脑电图方法，研究了完全睡眠剥夺对家鸽（Columba livia）发热反应的体温调节指标：脑温、外周血管反应、胸肌收缩活动、内毒素血症时躯体功能恢复及清醒和睡眠时间特征的影响。在给予LPS时慢波睡眠量增加的期间，睡眠剥夺诱导发热发作的潜伏期和发热持续时间减少，与单独LPS的作用相比，沿着脑温度和肌肉收缩活动水平更显著的增加。睡眠剥夺后的一段时间的特点是更长的恢复的肌肉收缩活动和睡眠和觉醒状态的时间特性，沿着更长的补偿性“反弹”的慢波睡眠相比，单独的睡眠剥夺的影响。因此，内毒素血症睡眠剥夺导致发热发作的潜伏期缩短，发热加重，生理功能恢复的潜伏期延长。
Electroencephalographic methods were used to study the effects of total sleep deprivation on thermoregulatory measures of the fever response in pigeons (Columba livia): brain temperature, peripheral vasomotor reactions, thoracic muscle contractile activity, and the recovery of somatic functions and the time characteristics of waking and sleep in lipopolysaccharide (LPS)-induced endotoxemia. Sleep deprivation during the period in which the quantity of slow-wave sleep increased on administration of LPS induced decreases in the latent period of fever onset and in the duration of fever, along with more significant increases in brain temperature and the level of muscle contractile activity as compared with the effects of LPS alone. The period after sleep deprivation was characterized by more prolonged recovery of muscle contractile activity and the time characteristics of sleep and waking states, along with more prolonged compensatory “rebound” of slow-wave sleep as compared with the effects of sleep deprivation alone. Thus, sleep deprivation in endotoxemia led to decreases in the latent period of fever onset, exacerbation of fever, and increases in the latent period of recovery of physiological functions.