Hypofunction of right temporoparietal cortex during emotional arousal in depression
Hypofunction of right temporoparietal cortex during emotional arousal in depression
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DOI：
10.1001/archpsyc.65.5.532
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发表时间：
2008-05-01
影响因子：
--
通讯作者：
Ortiz, Tomas
中科院分区：
文献类型：
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作者：
Moratti, Stephan;Rubio, Gabriel;Ortiz, Tomas
背景：抑郁症的神经心理学模型强调重度抑郁症（MDD）中与低情绪唤醒相关的颞顶叶功能减退。这些模型来源于间接测量，如神经心理测试和脑电图α带功率。目的：探讨高唤醒性刺激是否能直接调节重度抑郁症患者的注意和觉醒相关感觉脑区活动。设计：组间比较（重度抑郁症患者与健康对照）由闪烁的情绪图片和中性图片（稳态视觉诱发场[ssVEFs]）驱动的神经磁振荡活动。地点：一所公立大学的脑磁图中心和公共流动心理健康服务中心。参与者：15名女性重度抑郁症低焦虑患者和15名女性对照。这些小组根据年龄和用手习惯进行匹配。干预：脑磁图记录和自我报告评分。主要结果测量：通过ssvef的频域最小范数源定位获得的电流源强度调制。结果：对照组和重度抑郁症患者在高唤醒情绪图像时枕叶和顶叶皮质ssVEF频率电流源强度增强(P
Context: Neuropsychological models of depression highlight temporoparietal hypofunction associated with low emotional arousal in major depressive disorder (MDD). These models were derived from indirect measures such as neuropsychological tests and electroencephalography alpha band power.Objective: To determine if high-arousing stimuli directly modulated activity in attention and arousal-related sensory brain regions in patients with MDD.Design: Between-group comparison (patients with MDD vs healthy control subjects) of neuromagnetic oscillatory activity driven by flickering emotional and neutral pictures (steady-state visual evoked fields [ssVEFs]).Setting: Center of magnetoencephalography at a public university and public ambulatory mental health service.Participants: Fifteen female low-anxious patients with MDD and 15 female controls. The groups were matched with respect to age and handedness.Intervention: Magnetoencephalographic recordings and self-report ratings.Main Outcome Measures: Modulation of current source strengths obtained by frequency domain minimum norm source localization of ssVEFs.Results: Controls and patients with MDD showed enhanced current source strengths at ssVEF frequency in occipital and parietal cortex for high-arousing emotional pictures (P