A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents
A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents
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DOI：
10.1016/j.jconrel.2005.08.006
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发表时间：
2005-11-28
影响因子：
10.8
通讯作者：
Chen, WL
中科院分区：
文献类型：
--
作者：
Jiang, HL;Hu, YQ;Chen, WL
以聚己内酯（PCL）为壳层，聚乙二醇（PEG）为核，采用同轴静电纺丝技术制备了一种可生物降解的核-壳纳米纤维，用于BSA和溶菌酶两种模型蛋白的包埋和控制释放。核和壳的厚度可以通过内涂料的进料速率来调节，这反过来又影响掺入的蛋白质的释放曲线。结果表明，释放的溶菌酶保持了其结构和生物活性。目前的方法可能会在蛋白质的控制释放和组织工程中找到广泛的应用。(c)2005 Elsevier B. V.保留所有权利。
A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incorporated proteins. It was revealed that the released lysozyme maintained its structure and bioactivity. The current method may find wide applications for controlled release of proteins and tissue engineering. (c) 2005 Elsevier B.V. All rights reserved.