LONG-LASTING CHANGES IN LEVEL OF ELECTRICAL ACTIVITY OF CEREBRAL CORTEX PRODUCED BY POLARIZING CURRENTS
LONG-LASTING CHANGES IN LEVEL OF ELECTRICAL ACTIVITY OF CEREBRAL CORTEX PRODUCED BY POLARIZING CURRENTS
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DOI：
10.1038/196584a0
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发表时间：
1962-01-01
期刊：
影响因子：
64.8
通讯作者：
REDFEARN, JW
中科院分区：
文献类型：
--
作者：
BINDMAN, LJ;LIPPOLD, OCJ;REDFEARN, JW
由对侧大鼠前爪的感觉刺激诱发的皮层中的负电位波通过5-50 [mu]安培的表面正极化而增强，并且如果电流通过的持续时间为5分钟或更长，则在极化电流关闭后这种增强继续。在许多情况下，这种效果持续3小时或更长时间。同样，表面负电流引起了一个持久的诱发电位的大小减少。除了在诱发电位的大小的变化有增加的一般活动水平的皮层神经元在通过表面正电流;这种效果也持续后，极化被中断，在一些实验中超过4小时。
The negative potential wave in the cortex evoked by sensory stimulation of the contralateral rat forepaw was enhanced by surface-positive polarization of 5-50 [mu]amp and that if the duration of passage of current was 5 minutes or more, this enhancement continued after the polarizing current was switched off. In many cases this effect lasted for 3 hours or longer. Similarly, surface-negative currents gave rise to a long-lasting diminution in the size of the evoked potential. In addition to the change in the size of the evoked potential there was an increase in the level of general activity of the cortical neurons during the passage of surface-positive current; this effect also persisted after the polarization was discontinued, in some experiments for longer than 4 hours.