A STUDY OF THIRST AND OTHER EFFECTS OF AN INCREASED SODIUM CONCENTRATION IN 3RD BRAIN VENTRICLE
A STUDY OF THIRST AND OTHER EFFECTS OF AN INCREASED SODIUM CONCENTRATION IN 3RD BRAIN VENTRICLE
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DOI：
10.1111/j.1748-1716.1967.tb03488.x
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发表时间：
1967-01-01
期刊：
影响因子：
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通讯作者：
OLSSON, K
中科院分区：
文献类型：
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作者：
ANDERSSON, B;JOBIN, M;OLSSON, K
本文研究了山羊第三脑室注射高渗氯化钠溶液所致口渴的特点。在正常水平衡状态下，动物在2min内喝水1.5~2.01。脑室注射0.1ml0.85[图像]氯化钠后。在补充水分的动物中，这种口渴反应明显减弱或完全消失。如果不允许山羊在脑室注射高渗氯化钠后立即解渴，喝水的冲动逐渐减弱，大约20分钟后消失。单次或重复向第三脑室注射0.1ml0.85[图像]氯化钠可显著增加尿钠和氯离子的排泄，并可暂时抑制已建立的利水作用。醛固酮治疗不能阻止向第三脑室注射高渗氯化钠后尿液电解质排泄的增加。向第三脑室重复注射0.1ml0.85NH4CI或1.7d-葡萄糖，或向侧脑室注射0.1ml0.85[图像]氯化钠，均未引起饮酒或尿液电解质排泄增加。
The characteristics of thirst elicited by injections of hypertonic NaCl-solution into the 3rd brain ventricle were studied in goats supplied with permanent ventricular cannulae. Animals in normal water balance drank 1.5 to 2.0 1 of water within 2 min. after the intraventricular injection of 0.1 ml of 0.85 [image] NaCl. In the hydrated animal this thirst response was markedly diminished or completely absent. If the goats were not allowed to quench their thirst immediately after the intraventricular injection of hypertonic NaCl, the urge to drink gradually became weaker and disappeared after about 20 min. Single or repetitive injections of 0.1 ml of 0.85 [image] NaCl into the 3rd brain ventricle were further found to cause a conspicuous increase in urinary excretion of Na+ and Cl- and to inhibit temporarily an established water diuresis. Aldosterone treatment did not prevent the increase in urinary electrolyte excretion occurring after injections of hypertonic NaCl into the 3rd ventricle. Repetitive injections of 0.1 ml of 0.85 [image] NH4CI or of 1.7 [image] d-glucose into the 3rd ventricle, or injections of 0.1 ml of 0.85 [image] NaCl into the lateral ventricle did not induce drinking or cause any increase in urinary electrolyte excretion.