A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy
A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy
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DOI：
10.1039/c8cc02739k
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发表时间：
2018-06-11
影响因子：
4.9
通讯作者：
Pei, Zhichao
中科院分区：
文献类型：
--
作者：
Yang, Kui;Wen, Jia;Pei, Zhichao
以水溶性柱[6]芳烃和光敏剂亚甲基蓝（MB）为原料，通过主客体相互作用合成了超分子光敏剂体系WP 6-MB。MB可以直接与WP 6络合，络合常数高，无需进一步修饰。特别是WP 6-MB能显著降低MB的暗毒性。此外，它可以有效地克服光漂白和延长单线态氧产生的MB在光照射的时间，这是持久的光动力学治疗的意义。
A supramolecular photosensitizer system WP6-MB was synthesized based on water-soluble pillar[6] arene and the photosensitizer methylene blue (MB) via host-guest interaction. MB can complex with WP6 directly with a high complex constant without further modification. In particular, WP6-MB can reduce the dark toxicity of MB remarkably. Furthermore, it can efficiently overcome photobleaching and extend the time for singlet oxygen production of MB upon light irradiation, which is significant for durable photodynamic therapy.