Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near-Infrared Window
Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near-Infrared Window
复制标题
用于第二近红外窗口生物医学成像和手术导航的可排泄式镧系元素纳米颗粒
DOI：
10.1002/advs.201902042
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发表时间：
2019-12-04
期刊：
影响因子：
15.1
通讯作者：
Cheng, Zhen
中科院分区：
文献类型：
--
作者：
Li, Daifeng;He, Shuqing;Cheng, Zhen
近年来，各种第二近红外窗口（NIR-II, 1000-1700 nm）荧光团被合成用于无辐射、高分辨率、低自荧光的体内成像。然而，大多数NIR-II荧光团，特别是无机纳米探针，主要保留在网状内皮系统（RES）中，如肝脏和脾脏，导致长期安全性问题。本文报道了一种基于镧系元素可排泄的NIR-II纳米颗粒RENPs@Lips，该纳米颗粒可在静脉给药后迅速从体内清除，肝脏半衰期为23.0 h，脾脏半衰期为14.9 h。有趣的是，超过90%的RENPs@Lips可在注射后72小时内通过肝胆系统排出体外。适度的血液半衰期（T-1/2 = 17.96分钟）允许在描述血管疾病（动脉血栓、缺血和肿瘤血管生成）的血流动力学和监测急性缺血反应的血液灌注方面的多功能应用。此外，在NIR-II成像导航下，RENPs@Lips在术中识别原位肿瘤血管和栓塞手术中表现出很高的性能。此外，成功地实现了良好的信号背景比（SBR），以促进荷瘤小鼠前哨淋巴结活检（SLNB）。高生物相容性，良好的排泄性和杰出的光学特性使RENPs@Lips成为未来应用和转化为不同领域跨学科融合研究的新型有前途的NIR-II纳米颗粒。
Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained in the reticuloendothelial system (RES) such as the liver and spleen, leading to long-term safety concerns. Herein, a type of lanthanide-based excretable NIR-II nanoparticle, RENPs@Lips, which can be quickly cleared out of body after intravenous administration with half-lives of 23.0 h for the liver and 14.9 h for the spleen, is reported. Interestingly, over 90% of RENPs@Lips can be excreted through a hepatobiliary system within 72 h postinjection. The moderate blood half-time (T-1/2 = 17.96 min) allows for multifunctional applications in delineating the hemodynamics of vascular disorders (artery thrombosis, ischemia, and tumor angiogenesis) and monitoring blood perfusion in response to acute ischemia. In addition, RENPs@Lips exhibit high performance in identifying orthotopic tumor vessels intraoperatively and embolization surgery under NIR-II imaging navigation. Moreover, excellent signal-to-background ratio (SBR) is successfully achieved to facilitate sentinel lymph nodes biopsy (SLNB) with tumor-bearing mice. The high biocompatibility, favorable excretability, and outstanding optical properties warrant RENPs@Lips as novel promising NIR-II nanoparticles for future applications and translation into an interdisciplinary amalgamation of research in diverse fields.