Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.
Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.
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DOI：
10.4103/2045-9912.222448
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发表时间：
2017-10
影响因子：
2.9
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Mizuno K;Sasaki AT;Ebisu K;Tajima K;Kajimoto O;Nojima J;Kuratsune H;Hori H;Watanabe Y
健康和充满活力的生活是每个人都在追求的。为了提高生活质量（QOL），保持健康状态，预防各种疾病，评估潜在的QOL增加因素的影响是重要的。慢性氧化应激和炎症导致中枢神经系统功能恶化，导致生活质量低下。在健康个体中，衰老、工作压力和几个小时的认知负荷也会引起氧化应激的增加，这表明防止由日常压力和日常工作引起的氧化应激的积累有助于维持QOL和改善衰老的影响。氢具有抗氧化活性，可以预防炎症，因此可能有助于改善QOL。本研究旨在通过心理生理学测试，包括问卷调查、自主神经功能和认知功能测试，探讨饮用富氢水对成年志愿者生活质量的影响。在这项采用双向交叉设计的双盲、安慰剂对照研究中，26名志愿者（13名女性，13名男性;平均年龄34.4 ± 9.9岁）被随机分配至口服HRW（600 mL/d）或安慰剂水（PLW，600 mL/d）组，持续4周。HRW给药后静息状态下K6评分和交感神经活性的变化率（治疗后/治疗前）显著低于PLW给药后。这些结果表明，HRW可能会通过增强中枢神经系统功能（包括情绪、焦虑和自主神经功能）来增强生活质量。
Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several hours also induce increases in oxidative stress, suggesting that preventing the accumulation of oxidative stress caused by daily stress and daily work contributes to maintaining QOL and ameliorating the effects of aging. Hydrogen has anti-oxidant activity and can prevent inflammation, and may thus contribute to improve QOL. The present study aimed to investigate the effects of drinking hydrogen-rich water (HRW) on the QOL of adult volunteers using psychophysiological tests, including questionnaires and tests of autonomic nerve function and cognitive function. In this double-blinded, placebo-controlled study with a two-way crossover design, 26 volunteers (13 females, 13 males; mean age, 34.4 ± 9.9 years) were randomized to either a group administered oral HRW (600 mL/d) or placebo water (PLW, 600 mL/d) for 4 weeks. Change ratios (post-treatment/pre-treatment) for K6 score and sympathetic nerve activity during the resting state were significantly lower after HRW administration than after PLW administration. These results suggest that HRW may reinforce QOL through effects that increase central nervous system functions involving mood, anxiety, and autonomic nerve function.