A PHASE OF LIPOSOMES WITH ENTANGLED TUBULAR VESICLES
A PHASE OF LIPOSOMES WITH ENTANGLED TUBULAR VESICLES
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DOI：
10.1126/science.7973704
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发表时间：
1994-11-18
期刊：
影响因子：
56.9
通讯作者：
SAFINYA, CR
中科院分区：
文献类型：
--
作者：
CHIRUVOLU, S;WARRINER, HE;SAFINYA, CR
已经确定了属于二肉豆蔻酰磷脂酰胆碱（DMPC），水和香叶醇（一种生物醇，来自油溶性维生素，作为助表面活性剂）的三元混合物中的双层脂质体家族的平衡相。电子和光学显微镜显示相，标记L（电视），是由高度纠缠的管状囊泡。原位X射线衍射证实，小管壁是多层的，脂质处于链熔融状态。宏观观察表明，L（tv）相共存与众所周知的L（4）相的球形囊泡和散装L（α）相。然而，L（tv）相的定义特征是剪切下的Weissenberg爬杆效应，这是由其聚合物般的纠缠微结构引起的。
An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled L(tv), to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the L(tv) phase coexists with the well-known L(4) phase of spherical vesicles and a bulk L(alpha) phase. However, the defining characteristic oi the L(tv) phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.