Antimicrobial peptides with cell-penetrating peptide properties and vice versa
Antimicrobial peptides with cell-penetrating peptide properties and vice versa
复制标题
DOI：
10.1007/s00249-011-0682-7
复制
发表时间：
2011-04-01
影响因子：
2
通讯作者：
Neundorf, Ines
中科院分区：
文献类型：
--
作者：
Splith, Katrin;Neundorf, Ines
抗菌肽（Antimicrobial peptides，AMP）是一类对多种微生物具有抗菌活性的多肽。由于其作用模式，AMP是一类有前途的分子，可以克服细菌对常规抗生素耐药性增加的问题。此外，AMP是强膜活性的，并且一些AMP能够易位到细胞中而不需要永久的膜透化。这一特征使它们成为药物递送背景下用作转运载体的焦点。由于质膜限制了生物活性物质进入细胞的运输，因此极大的研究兴趣在于开发克服这一障碍并提高生物利用度的创新方法。在这种情况下，基于肽的转运系统，如细胞穿透肽（CPP），已成为焦点，其效率已在许多不同的应用中得到证明。然而，最近，一些AMP也已被用作各种活性分子的细胞内易位的有效载体。本文综述了最近的努力，在这个有趣的领域的药物输送。此外，将讨论CPP作为有效的抗菌物质的应用的一些例子。
Antimicrobial peptides (AMPs) are a group of peptides that are active against a diverse spectrum of microorganisms. Due to their mode of action, AMPs are a promising class of molecules that could overcome the problems of increasing resistance of bacteria to conventional antibiotics. Furthermore, AMPs are strongly membrane-active and some are able to translocate into cells without the necessity for permanent membrane permeabilization. This feature has brought them into focus for use as transport vectors in the context of drug delivery. Since the plasma membrane restricts transport of bioactive substances into cells, great research interest lies in the development of innovative ways to overcome this barrier and to increase bioavailability. In this context, peptide-based transport systems, such as cell-penetrating peptides (CPPs), have come into focus, and their efficiency has been demonstrated in many different applications. However, more recently, also some AMPs have been used as efficient vectors for intracellular translocation of various active molecules. This review summarizes recent efforts in this interesting field of drug delivery. Moreover, some examples of the application of CPPs as efficient antimicrobial substances will be discussed.