EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10
EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10
复制标题
EphA8 作为癌基因，通过调节 ADAM10 导致胃癌预后不良
DOI：
10.1002/jcp.28642
复制
发表时间：
2019-11-01
影响因子：
5.6
通讯作者：
Huang, Jianfei
中科院分区：
文献类型：
--
作者：
Wang, Yingjing;Zhou, Nan;Huang, Jianfei
EphA8是产生红细胞生成素的肝细胞受体（Eph）受体酪氨酸激酶家族的成员。ephs及其配体通过介导细胞间相互作用产生的细胞内信号转导在许多细胞过程中起着至关重要的作用。但EphA8在胃癌中的作用机制尚不清楚。在298例临床标本的组织芯片中，发现胃癌组织中的表达显著高于非肿瘤组织（p
EphA8 is a member of the erythropoietin-producing hepatocellular receptor (Eph) family of receptor tyrosine kinases. Ephs and their ephrins ligands play crucial roles in many cellular processed by mediating intracellular signaling resulting from cell-cell interactions. But the underlying mechanisms of EphA8 in gastric cancer (GC) remains unclearly. 298 clinical specimens in tissues microarray, and was found to be significantly higher in GC tissues compared with nontumor tissues (p