Measuring absorption coefficients in small volumes of highly scattering media: Source-detector separations for which path lengths do not depend on scattering properties
Measuring absorption coefficients in small volumes of highly scattering media: Source-detector separations for which path lengths do not depend on scattering properties
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DOI：
10.1364/ao.36.005655
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发表时间：
1997-08-01
期刊：
影响因子：
1.9
通讯作者：
Miller, HD
中科院分区：
文献类型：
--
作者：
Mourant, JR;Bigio, IJ;Miller, HD
在许多临床环境中，对由于组织中生化相关化合物浓度变化引起的吸收变化进行无创测量非常重要。这种测量的一个问题是所收集的光穿过组织行进的路径长度取决于组织的散射特性。我们使用蒙特卡罗模拟和实验测量证明，对于光传输和光收集光纤之间的适当分离，所收集光子的路径长度不依赖于组织中通常存在的参数范围的散射参数。这对于开发快速、无创且廉价的测量组织吸收变化的方法非常重要。 (C) 1997 年美国光学学会。
The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the path length traveled by the collected light through the tissue depends on the scattering properties of the tissue. We demonstrate, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light collection fibers the path length of the collected photons does not depend on scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, and inexpensive methods for measuring absorption changes in tissue. (C) 1997 Optical Society of America.