Effect of morroniside on the transcriptome profiles of rat in injured spinal cords.
Effect of morroniside on the transcriptome profiles of rat in injured spinal cords.
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DOI：
10.1016/j.gene.2022.146338
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发表时间：
2022-03
期刊：
影响因子：
3.5
通讯作者：
Yu-Jiao Shi;Wenjie Sheng;Meng-Tong Xue;Feixiang Duan;Lin Shen;Shu-qin Ding;Qiyi Wang;Rui Wang
中科院分区：
文献类型：
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作者：
Yu-Jiao Shi;Wenjie Sheng;Meng-Tong Xue;Feixiang Duan;Lin Shen;Shu-qin Ding;Qiyi Wang;Rui Wang
We have previously reported that morroniside promoted motor activity after spinal cord injury (SCI) in rats. However, the mechanism by which morroniside induces recovery of injured spinal cord (SC) remains unknown. In the current study, RNA sequencing (RNA-seq) was employed to evaluate changes of gene expressions at the transcriptional level of the injured spinal cords in morroniside-administrated rats. Principal component analysis, analysis of enriched Gene Ontology (GO), enrichment analyses Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and other bioinformatics analyses were executed to distinguish differentially expressed genes (DEGs). The results of RNA-seq confirmed the anti-inflammatory and anti-apoptotic effects of morroniside on injured SC tissues, and provided the basis for additional research of the mechanisms involving the protective effects of morroniside on SCI.
