MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies
MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies
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DOI：
10.1109/tns.2013.2294829
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发表时间：
2014-02-01
影响因子：
1.8
通讯作者：
King, Michael A.
中科院分区：
文献类型：
--
作者：
Dasari, Paul;Johnson, Karen;King, Michael A.
心脏的呼吸运动影响心肌灌注发射成像研究的诊断准确性。幅度入库已成为PET和SPECT中用于校正呼吸运动的基于入库列表模式的采集的选择方法。在某些受试者中，呼吸运动表现出类似于受阻的非线性循环系统的迟滞行为。检测和纠正来自病人身体表面运动的信号和心脏在胸腔内的运动之间的滞后仍然是一个有待研究的领域。这项研究报告了我们对9名志愿者使用导航仪和视觉跟踪系统(VTS)立体跟踪志愿者胸部和腹部标志物的联合MRI跟踪心脏内部呼吸运动的研究。对来自内部器官和外部标志物的呼吸运动信号进行滞后行为评估，分析信号的时间对应关系。总体而言，在呼吸过程中，外部标志物运动(AP方向)和心脏内部运动(SI方向)之间存在强烈的正相关。9名受试者的Spearman‘s等级相关系数(Rho)的平均正/负标准差分别为0.92+/-0.1和0.87+/-0.2。然而，尽管九名志愿者的平均相关性很好，但在三项研究中，由于胸部标记和心脏内部运动，或者腹部标记和心脏运动的吸气和呼气之间的滞后行为，相关性较差。在所有病例中，我们观察到至少腹部或胸部与心脏有很好的相关性。基于这一结果，我们提出了在估计心脏内部运动时使用来自胸部和腹部区域的标记运动来检测和解决列表模式发射数据入库时的滞后问题。
Respiratory motion of the heart impacts the diagnostic accuracy of myocardial-perfusion emission-imaging studies. Amplitude binning has come to be the method of choice for binning list-mode based acquisitions for correction of respiratory motion in PET and SPECT. In some subjects respiratory motion exhibits hysteretic behavior similar to damped non-linear cyclic systems. The detection and correction of hysteresis between the signals from surface movement of the patient's body used in binning and the motion of the heart within the chest remains an open area for investigation. This study reports our investigation in nine volunteers of the combined MRI tracking of the internal respiratory motion of the heart using Navigators with stereo-tracking of markers on the volunteer's chest and abdomen by a visual-tracking system (VTS). The respiratory motion signals from the internal organs and the external markers were evaluated for hysteretic behavior analyzing the temporal correspondence of the signals. In general, a strong, positive correlation between the external marker motion (AP direction) and the internal heart motion (SI direction) during respiration was observed. The average +/- standard deviation in the Spearman's ranked correlation coefficient (rho) over the nine volunteer studied was 0.92 +/- 0.1 between the external abdomen marker and the internal heart, and 0.87 +/- 0.2 between the external chest marker and the internal heart. However despite the good correlation on average for the nine volunteers, in three studies a poor correlation was observed due to hysteretic behavior between inspiration and expiration for either the chest marker and the internal motion of the heart, or the abdominal marker and the motion of the heart. In all cases we observed a good correlation of at least either the abdomen or the chest with the heart. Based on this result, we propose the use of marker motion from both the chest and abdomen regions when estimating the internal heart motion to detect and address hysteresis when binning list-mode emission data.