Cortical networks for working memory and executive functions sustain the conscious resting state in man
Cortical networks for working memory and executive functions sustain the conscious resting state in man
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DOI：
10.1016/s0361-9230(00)00437-8
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发表时间：
2001-02-01
影响因子：
3.8
通讯作者：
Tzourio-Mazoyer, N
中科院分区：
文献类型：
--
作者：
Mazoyer, B;Zago, L;Tzourio-Mazoyer, N
通过对九个正电子发射断层扫描 (PET) 激活协议的荟萃分析，研究了有意识静息状态 (REST) 的皮质解剖结构，这些协议处理不同的认知任务，但将 REST 作为共同的控制状态。在休息期间，受试者处于黑暗和沉默中，并被指示放松，不要移动，并避免系统性思考。每个协议将 REST 与不同的认知任务进行对比，该任务包括语言、心理意象、心理计算、推理、手指运动或空间工作记忆，使用听觉、视觉汽车，无刺激传递，并且需要声音、运动或无输出。总共 63 名受试者和 370 幅空间标准化 PET 扫描被纳入荟萃分析。联合分析显示，与九个认知任务相比，在有意识的休息期间联合激活的大脑区域网络，包括双侧角回、左前楔前叶和后扣带皮层、左内侧额叶和前扣带皮层、左额上沟和内侧额沟以及左额下皮层。这些结果表明，有意识休息期间的大脑活动是由一个大规模的异模态关联顶叶和额叶皮质区域网络来维持的，该网络可以在情景工作记忆顶叶网络中进一步分层组织，部分由情绪驱动，在执行左前额叶网络的监督下工作。 (C) 2001 爱思唯尔科学公司。
The cortical anatomy of the conscious resting state (REST) was investigated using a meta-analysis of nine positron emission tomography (PET) activation protocols that dealt with different cognitive tasks but shared REST as a common control state. During REST, subjects were in darkness and silence, and were instructed to relax, refrain from moving, and avoid systematic thoughts. Each protocol contrasted REST to a different cognitive task consisting either of language, mental imagery, mental calculation, reasoning, finger movement, or spatial working memory, using either auditory, visual car no stimulus delivery, and requiring either vocal, motor or no output. A total of 63 subjects and 370 spatially normalized PET scans were entered in the meta-analysis. Conjunction analysis revealed a network of brain areas jointly activated during conscious REST as compared to the nine cognitive tasks, including the bilateral angular gyrus, the left anterior precuneus and posterior cingulate cortex, the left medial frontal and anterior cingulate cortex, the left superior and medial frontal sulcus, and the left inferior frontal cortex. These results suggest that brain activity during conscious REST is sustained by a large scale network of heteromodal associative parietal and frontal cortical areas, that can be further hierarchically organized in an episodic working memory parieto-frontal network, driven in part by emotions, working under the supervision of an executive left prefrontal network. (C) 2001 Elsevier Science Inc.