Polycystic ovaries in childhood: a common finding in daughters of PCOS patients. A pilot study
Polycystic ovaries in childhood: a common finding in daughters of PCOS patients. A pilot study
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DOI：
10.1093/humrep/17.3.771
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发表时间：
2002-03-01
影响因子：
6.1
通讯作者：
Venturoli, S
中科院分区：
文献类型：
--
作者：
Battaglia, C;Regnani, G;Venturoli, S
背景技术背景：多囊卵巢综合征（PCOS）是一种有争议的内分泌病理学，最近有人认为这种情况是遗传性的。本研究的目的是通过超声（US）和彩色多普勒分析，前瞻性地确定PCOS患者的女儿中多囊卵巢的发生率，并寻找与特定激素参数的任何相关性。方法：15个青春期前的后代（组1）与PCOS患者和10个正常对照青春期前的女孩（组II）提交的临床，生长，和基础激素测定。此外，所有患者均接受超声和彩色多普勒卵巢和子宫评估。结果：在第一组女孩中，多囊卵巢的患病率为93%，而在第二组中没有受试者患有多囊卵巢。卵巢体积（2.76 ± 1.21 ml）和小卵泡数（5.36 ± 2.2 vs 0.75 ± 0.92; P <0.001）均显著高于Ⅱ组。此外，在对照组中观察到正常的基质评分和缺乏基质血管形成。两组之间的激素水平没有差异。结论：总之，我们推测，多囊卵巢在儿童时期可能被认为是遗传易感性PCOS的一个标志，环境因素可能表达成人临床和激素的综合征。
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a controversial endocrine pathology and, recently, it has been suggested that the condition is hereditary. The aim of this study was to prospectively determine in daughters of patients with PCOS, by ultrasonographic (US) and colour Doppler analyses, the incidence of polycystic ovaries and search any correlation with specific hormonal parameters. METHODS: Fifteen prepubertal offspring (Group 1) of patients with PCOS and 10 normal control prepubertal girls (Group II) were submitted to clinical, auxological, and basal hormonal assay. In addition all patients were submitted to US and colour Doppler ovarian and uterine evaluation. RESULTS: Among Group I girls the prevalence of polycystic ovaries was 93%, whereas no subjects among Group II had polycystic ovaries. The ovarian volume (2.76 +/- 1.21 ml versus 0.87 +/- 0.46 ml; P < 0.001) and the number of small sized follicles (5.36 ± 2.2 versus 0.75 ± 0.92; P < 0.001) were significantly higher in Group I than Group II patients. In addition, a normal stromal score and an absent stromal vascularization was observed in the control group. The hormone levels did not differ between the two groups. CONCLUSION: In conclusion we speculate that polycystic ovaries in childhood may be considered a sign of genetic predisposition to PCOS and that environmental factors may express the adult clinical and hormonal presentation of the syndrome.