Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration.
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration.
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DOI：
10.4161/bioa.25744
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Rivera GM
中科院分区：
文献类型：
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作者：
Chaki SP;Rivera GM
上皮细胞和内皮细胞的平面极化和顶底极化在形态发生过程中起着至关重要的作用。这些不同极性状态的建立和它们的转变受信号网络的调控，这些信号网络包括极性复合体、Rho GTP酶和磷脂酰肌醇。这些分子对信号的时空协调调节细胞骨架重塑和囊泡运输，以指定膜域，这是组织和器官组织的先决条件。在这里，我们概述了Nck激活肌动蛋白重塑的WASP/Arp2/3通路如何协调细胞的定向迁移，并推测它在协调内皮细胞极性和血管腔形成的细胞过程中扮演着信号整合者的角色。
Planar and apical-basal cellular polarization of epithelia and endothelia are crucial during morphogenesis. The establishment of these distinct polarity states and their transitions are regulated by signaling networks that include polarity complexes, Rho GTPases, and phosphoinositides. The spatiotemporal coordination of signaling by these molecules modulates cytoskeletal remodeling and vesicle trafficking to specify membrane domains, a prerequisite for the organization of tissues and organs. Here we present an overview of how activation of the WASp/Arp2/3 pathway of actin remodeling by Nck coordinates directional cell migration and speculate on its role as a signaling integrator in the coordination of cellular processes involved in endothelial cell polarity and vascular lumen formation.