Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets.
Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets.
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DOI：
10.3389/fcimb.2022.832254
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
肺炎链球菌是一种机会性病原体，尽管有几种多价肺炎球菌结合疫苗（PCVs）可用，但每年仍导致100多万人死亡。由于pcv的局限性以及抗生素耐药和未包封菌株的进化增加，保守的免疫原性蛋白作为疫苗靶点仍然是肺炎球菌疾病预防的重要研究领域。在这篇综述中，我们概述了已研究的多种保守表面蛋白对肺炎球菌毒力的贡献。此外，我们还讨论了在对这些蛋白的反应中观察到的免疫反应及其作为疫苗靶点的前景。
Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets.
影响因子：
3.7
作者：
Paschall AV;Middleton DR;Wantuch PL;Avci FY
通讯作者：
Avci FY
影响因子：
4.8
作者：
Ochs MM;Williams K;Sheung A;Lheritier P;Visan L;Rouleau N;Proust E;de Montfort A;Tang M;Mari K;Hopfer R;Gallichan S;Brookes RH
通讯作者：
Brookes RH