Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals.
Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals.
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检测间歇性内分泌信号的敏感性和阳性准确性的生物物理模型。
DOI：
10.1152/ajpendo.1989.257.1.e88
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Veldhuis,JD
中科院分区：
文献类型：
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作者：
Urban,RJ;Johnson,ML;Veldhuis,JD
为了研究内分泌信号检测中假阴性和假阳性错误的性质，我们使用多参数卷积过程来创建随机激素分泌爆发。我们观察到：1）包含高信号频率、振幅和/或持续时间的数据可以在不太严格的峰值检测阈值下进行分析; 2）对于任何给定的分泌爆发振幅，增加峰值检测阈值可以提高正准确性，但降低灵敏度; 3）增加采样频率可以提高灵敏度，但需要更严格的峰值检测阈值;以及4）增加的噪声降低了灵敏度和正精度。我们得出结论，分泌特性，峰值检测器阈值，振荡器指定的采样强度，和实验方差都显着影响假阳性和假阴性错误与情节性内分泌脉冲信号的计数。本文的观察结果为脉动生理现象的神经内分泌研究的合理设计和分析提供了客观的原则。
To investigate the nature of false-negative and false-positive errors in endocrine signal detection, we used a multiparameter convolution procedure to create random hormone secretory bursts. We observed that 1) data containing high signal frequency, amplitude, and/or duration can be analyzed at less stringent peak-detection thresholds; 2) for any given secretory burst amplitude, increasing the peak-detection threshold enhances positive accuracy but decreases sensitivity; 3) increased sampling frequency improves sensitivity but requires more stringent peak-detection thresholds; and 4) increasing noise diminishes both sensitivity and positive accuracy. We conclude that secretory properties, peak-detector thresholds, investigator-specified sampling intensity, and experimental variance all significantly influence false-positive and false-negative errors associated with the enumeration of episodic endocrine pulse signals. The present observations should offer objective principles to aid in the rational design and analysis of neuroendocrine studies of pulsatile physiological phenomena.