Salient Measures of Inhibition and Switching Are Associated With Frontal Lobe Gray Matter Volume in Healthy Middle-Aged and Older Adults
Salient Measures of Inhibition and Switching Are Associated With Frontal Lobe Gray Matter Volume in Healthy Middle-Aged and Older Adults
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DOI：
10.1037/neu0000082
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发表时间：
2014-11-01
期刊：
影响因子：
2.4
通讯作者：
Lundervold, Astri J.
中科院分区：
文献类型：
--
作者：
Adolfsdottir, Steinunn;Haasz, Judit;Lundervold, Astri J.
目的：探讨脑形态测量指标与显著执行功能(EF)抑制和转换指标之间的脑行为关系。方法：采用DELIS-Kaplan执行功能系统(D-KEFS)对100名被试(49-80岁)进行颜色词干扰测试。使用线性模型和条件推理树分析了抑制和转换的EF成分的显著测量，其中更基本的技能的影响被回归，并考虑了预测变量(脑容量、年龄、性别和教育)之间的相互关系。结果：条件推理树分析表明，额中回(MFG)在解释转换和联合抑制/转换显著EF测量的变化中起主要作用。年龄预示着抑制的程度。结论：在解释标准EF测试结果时，这项研究强调了考虑基本认知技能和使用统计方法的重要性，并考虑到预测变量之间可能存在的复杂关系。进一步的研究应该包括代表可能与CWIT表现相关的神经网络的MRI测量，并需要进行纵向研究来调查任何因果关系。
Objective: To investigate brain-behavior relationships between morphometric brain measures and salient executive function (EF) measures of inhibition and switching. Method: One hundred participants (49-80 years) performed the Color Word Interference Test from the Delis-Kaplan Executive Function System (D-KEFS). Salient measures of EF components of inhibition and switching, of which the effect of more fundamental skills were regressed out, were analyzed using linear models and a conditional inference trees analysis taking intercorrelations between predictor variables (brain volumes, age, gender, and education) into account. Results: The conditional inference trees analysis demonstrated a primary role of the middle frontal gyrus (MFG) in explaining variations in the salient EF measure of switching and combined inhibition/switching. Age predicted measures of inhibition. Conclusion: The study highlights the importance of considering fundamental cognitive skills and the use of a statistical method taking possible complex relationships between predictor variables into account when interpreting standard EF test results. Further studies should include MRI measures representing neural networks that may relate to CWIT performance, and longitudinal studies are required to investigate any causal relationships.