CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.
CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.
复制标题
CD4 T 细胞可预防由委内瑞拉马脑炎病毒引起的急性致死性脑炎。
DOI：
10.1016/j.vaccine.2009.04.015
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发表时间：
2009
期刊：
影响因子：
5.5
通讯作者：
Paessler,Slobodan
中科院分区：
文献类型：
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作者：
Yun,NadezhdaE;Peng,Bi-Hung;Bertke,AndreaS;Borisevich,Viktoriya;Smith,JenniferK;Smith,JeanonN;Poussard,AllisonL;Salazar,Milagros;Judy,BarbaraM;Zacks,MicheleA;Estes,DMark;Paessler,Slobodan
研究病毒性脑炎导致宿主存活的机制对疫苗的开发至关重要。我们在几项独立研究中发现，在鼻内感染委内瑞拉马脑炎病毒之前，使用中和抗体进行高剂量治疗，即使在没有αβ T细胞的情况下，也能在内脏器官中产生抗病毒作用，并延长感染小鼠的存活时间。然而，抗体治疗并不能阻止致命性脑炎的发展。相反，在缺乏αβ T细胞受体的小鼠中，过继转移致敏的CD4+T细胞是预防致死性脑炎所必需的。
Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high-dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of αβ T cells. Nevertheless, the antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4+T cells is necessary to prevent lethal encephalitis in mice lacking αβ T cell receptor.