Disruption of local retinoid‐mediated gene expression accompanies abnormal development in the mammalian olfactory pathway
Disruption of local retinoid‐mediated gene expression accompanies abnormal development in the mammalian olfactory pathway
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局部视黄醇介导的基因表达的破坏伴随着哺乳动物嗅觉通路的异常发育
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
A. LaMantia
中科院分区：
文献类型：
--
作者：
R. Anchan;D. P. Drake;Charles F. Haines;E. Gerwe;A. LaMantia
我们评估了类视黄醛信号在嗅上皮和嗅球早期发育中的作用。当柠檬醛（一种被认为干扰类视黄醛合成的普通醇脱氢酶拮抗剂）在妊娠中期的小鼠胚胎中短暂阻断类视黄醛介导的基因表达时，形态发生异常包括嗅觉通路发育的中断。然而，评估这种药理学操作的特异性是困难的，因为它也损害了中枢神经系统发育的其他几个方面。在纯合子Pax6突变小鼠（小眼：Pax6Sey‐Neu）中，嗅觉通路存在更分散的病变：在发育过程中的任何时候都不能识别上皮和球，而其他前脑细分仍然可以识别。整个初级嗅觉通路的丧失伴随着类视黄酮介导的基因表达的失败，这种基因表达仅限于额鼻区和前脑。类视黄酮受体在Pax6Sey‐Neu/Pax6Sey‐Neu胚胎的前脑中表达，突变的前脑仍然对外源性视黄酸有反应。然而，在Pax6Sey‐Neu/Pax6Sey‐Neu胚胎中，视黄酸（RA）不是由额鼻间质产生的，而额鼻间质通常向位点和前脑提供局部视黄酸信号。总之，这些结果表明，局部类视黄醇信号对于哺乳动物嗅觉通路的正常发育至关重要。[j]中华神经科杂志，2004,32(1):1 - 4。©1997 Wiley‐Liss, Inc。
We have evaluated the role of retinoid signaling in the early development of the olfactory epithelium and olfactory bulb. When retinoid‐mediated gene expression is blocked briefly in mouse embryos at midgestation with citral (a general alcohol dehydrogenase antagonist that is thought to interfere with retinoid synthesis), the spectrum of morphogenetic abnormalities includes disruption of olfactory pathway development. It is difficult, however, to assess the specificity of this pharmacological manipulation, insofar as it also compromises several other aspects of central nervous system development. In homozygous Pax6 mutant mice (small eye: Pax6Sey‐Neu), there is a more discrete lesion to the olfactory pathway: The epithelium and bulb cannot be recognized at any time during development, whereas other forebrain subdivisions can still be recognized. This loss of the entire primary olfactory pathway is accompanied by a failure of retinoid‐mediated gene expression limited to the frontonasal region and forebrain. Retinoid receptors are expressed in the forebrain of Pax6Sey‐Neu/Pax6Sey‐Neu embryos, and the mutant forebrain remains responsive to exogenous retinoic acid. However, in Pax6Sey‐Neu/Pax6Sey‐Neu embryos, retinoic acid (RA) is not produced by the frontonasal mesenchyme, which normally provides local retinoid signals to the placode and forebrain. Together, these results suggest that local retinoid signaling is essential for the normal development of the mammalian olfactory pathway. J. Comp. Neurol. 379:171–184, 1997. © 1997 Wiley‐Liss, Inc.
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DOI：
10.1073/pnas.91.15.7194
发表时间：
1994-07
影响因子：
11.1
作者：
P. McCaffery;U. C. Dräger
通讯作者：
P. McCaffery;U. C. Dräger
视黄醇氧化为视黄酸是小鼠表皮生物活性的必要条件。
影响因子：
11.2
作者：
Connor,MJ
通讯作者：
Connor,MJ
DOI：
10.1073/pnas.89.8.3347
发表时间：
1992-04-15
影响因子：
11.1
作者：
BALKAN, W;COLBERT, M;LINNEY, E
通讯作者：
LINNEY, E
v-erbA 和柠檬醛分别降低全反式视黄酸和视黄醇在爪蟾胚胎发生中的致畸作用。
DOI：
10.1242/dev.119.3.785
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Schuh,TJ;Hall,BL;Kraft,JC;Privalsky,ML;Kimelman,D
通讯作者：
Kimelman,D
致畸剂和颅面畸形：与细胞死亡的关系。
DOI：
10.1242/dev.103.supplement.213
发表时间：
1988
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Sulik,KK;Cook,CS;Webster,WS
通讯作者：
Webster,WS