Health-related quality of life in French people living with HIV in 2003:: results from the national ANRS-EN12-VESPA Study
Health-related quality of life in French people living with HIV in 2003:: results from the national ANRS-EN12-VESPA Study
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DOI：
10.1097/01.aids.0000255081.24105.d7
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发表时间：
2007-01-01
期刊：
影响因子：
3.8
通讯作者：
Spire, Bruno
中科院分区：
文献类型：
--
作者：
Preau, Marie;Marcellin, Fabienne;Spire, Bruno
目的：自 HAART 出现以来，健康相关生活质量 (HRQL) 的评估已成为 HIV 感染者治疗随访中的主要关注点。设计：对 ANRS-EN12-VESPA 研究中的 2235 名参与者进行了 HRQL 评估。这些参与者完成了医疗结果研究 36 项简短健康调查 (MOS SF-36) 调查问卷。使用医院焦虑和抑郁（HAD）量表评估焦虑和抑郁。如果个人的 MOS SF-36 分数大于法国一般人群中相应年龄-性别特定分数分布的 25 小时百分位，则认为个人具有“可接受的”身体（和精神）HRQL。 方法：使用 Logistic 回归模型在人口、心理社会和临床特征中识别与“可接受的”身体和精神 HRQL 相关的因素。对 MOS SF-36 问卷的非随机缺失答复引起的潜在选择偏差进行了统计测试。结果：分别有 1176 名 (53%) 和 1152 名 (51%) 个体的身体和心理 HRQL 为“可接受”。在调整社会人口学因素、HIV临床状况和丙型肝炎合并感染、高HAD评分以及抗焦虑、抗抑郁和安眠药物的消耗后，发现与正常的身心HRQL呈负相关。结论：披露和歧视的作用是HRQL的决定因素，各种文化和心理维度需要进一步研究。其他感染或合并症的存在需要一个全面的护理系统，包括医务人员和社会工作者团队。艾滋病毒应越来越多地被视为一种以不同病理状况为特征的慢性疾病，需要采取全面和多学科的方法。 (c) 2007 年利平科特威廉姆斯和威尔金斯。
Objective: Since the advent of HAART, the assessment of health-related quality of life (HRQL) has become a major concern in the therapeutic follow-up of people living with HIV.Design: HRQL was evaluated for 2235 participants in the ANRS-EN12-VESPA Study. These participants completed the Medical Outcome Study 36-Item Short Form Health Survey (MOS SF-36) questionnaire. Anxiety and depression were assessed using the Hospital Anxiety and Depression (HAD) scale. Individuals were considered to have an 'acceptable' physical (and mental) HRQL if their MOS SF-36 scores were greater than the 25'h percentile of the corresponding age-sex-specific distribution of scores in the French general population.Methods: Logistic regression models were used to identify factors associated with an 'acceptable' physical and mental HRQL among demographic, psychosocial and clinical characteristics. Potential selection bias caused by non-random missing responses to the MOS SF-36 questionnaire was statistically tested.Results: Physical and mental HRQL were 'acceptable' in 1176 (53%) and 1152 (51%) individuals, respectively. After adjusting for sociodemographic factors, HIV clinical status and hepatitis C co-infection, high HAD scores and the consumption of anxiolytic, antidepressant and hypnotic drugs were found to be negatively associated with normal physical and mental HRQL.Conclusion: The role of disclosure and discrimination is determinant in HRQL, and the various cultural and psychological dimensions require further research. The presence of other infections or co-morbidities requires a comprehensive care system including medical staff and social worker teams. HIV should increasingly be regarded as a chronic disease characterized by different pathological conditions requiring a comprehensive and multidisciplinary approach. (c) 2007 Lippincott Williams & Wilkins.