Initial evidence of vowel space reduction in a subset of individuals with schizophrenia.
Initial evidence of vowel space reduction in a subset of individuals with schizophrenia.
复制标题
部分精神分裂症患者元音间距减少的初步证据。
DOI：
10.1016/j.schres.2023.03.026
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发表时间：
2023
影响因子：
4.5
通讯作者：
Compton,MichaelT
中科院分区：
文献类型：
--
作者：
Hogoboom,Anya;Rouch,Megan;Lauerman,Diana;Pauselli,Luca;Compton,MichaelT
声学语音测量已被发现与精神分裂症的阴性症状相关，从而提供了一条定量测量此类症状的途径。这些声学属性包括F1和F2测量值（分别受舌头高度和舌头前/后位置的影响），它们决定了一般的“元音空间”。在患者和对照组中，我们考虑两个语音措施的元音空间：平均欧几里得距离从一个参与者的平均值F1和平均值F2，和密度的元音周围的一个标准差的平均值F1和F2.MethodsStructured和自发语音的148名参与者（70例患者和78名对照）进行了记录和测量声学。我们研究了元音空间的语音测量值和使用两种临床研究测量值，阴性症状评估量表（SANS）和阴性症状临床评估访谈（CAINS. Results元音空间测量值与患者/对照状态显著相关，这归因于一组13名患者，其语音值对应于通过两种语音测量评估的减少的元音空间。语音测量与SANS和CAINS的相关项目和平均评分之间没有相关性。减少元音空间似乎只影响一个子集的精神分裂症患者，潜在的那些更高的抗精神病药物dose.ConclusionsAcoustic语音措施可能是更敏感的措施，收缩元音空间比临床研究评价尺度的韵律或单调的讲话。在进一步解释这一新发现（包括潜在的药物作用）之前，需要进行重复研究。
ObjectiveAcoustic phonetic measures have been found to correlate with negative symptoms of schizophrenia, thus offering a path toward quantitative measurement of such symptoms. These acoustic properties include F1 and F2 measurements (affected by tongue height and tongue forward/back position, respectively), which determine a general “vowel space.” Among patients and controls, we consider two phonetic measures of vowel space: average Euclidean distance from a participant's mean F1 and mean F2, and density of vowels around one standard deviation of mean F1 and of F2.MethodsStructured and spontaneous speech of 148 participants (70 patients and 78 controls) was recorded and measured acoustically. We examined correlations between the phonetic measures of vowel space and ratings of aprosody obtained using two clinical research measures, theScale for the Assessment of Negative Symptoms(SANS) and theClinical Assessment Interview for Negative Symptoms(CAINS).ResultsVowel space measurements were significantly associated with patient/control status, attributed to a cluster of 13 patients whose phonetic values correspond to reduced vowel space as assessed by both phoenetic measures. No correlation was found between phonetic measures and relevant items and averages of ratings on the SANS and CAINS. Reduced vowel space appears to affect only a subset of patients with schizophrenia, potentially those on higher antipsychotic dosages.ConclusionsAcoustic phonetic measures may be more sensitive measures of constricted vowel space than clinical research rating scales of aprosody or monotone speech. Replications are needed before further interpretation of this novel finding, including potential medication effects.