High syndecan-1 expression is associated with favourable outcome in squamous cell lung carcinoma treated with radical surgery
High syndecan-1 expression is associated with favourable outcome in squamous cell lung carcinoma treated with radical surgery
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DOI：
10.1016/s0169-5002(00)00230-0
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发表时间：
2001-06-01
期刊：
影响因子：
5.3
通讯作者：
Joensuu, H
中科院分区：
文献类型：
--
作者：
Anttonen, A;Heikkilä, P;Joensuu, H
syndecan-1的表达在许多细胞转化模型中下调。我们研究了syndecan-1在116例肺鳞癌根治术后表达的临床意义。石蜡包埋的组织样品用抗人多配体蛋白聚糖-1（B-B4和104-9）的两种抗体免疫染色。高分化癌中的多配体蛋白聚糖-1表达高于中等或低分化癌（对于B-B4，P = 0.001;对于104-9，P < 0.0001）。但未发现与原发肿瘤大小（T分期）或临床分期的显著相关性。以中位表达（B-B4染色阳性的癌细胞的10%）作为临界值。高表达的癌症比低表达的癌症具有更有利的生存率（校正并发死亡的2年生存率为84%对61%）。P = 0.026）。然而，在多变量生存分析中，syndecan-1表达不是独立的预后因素。我们的结论是syndecan-1表达减少与肺鳞状细胞癌的组织学去分化平行，低syndecan-1表达与不利的结果。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Expression of syndecan-1 is down-regulated in many cellular transformation models. We studied the clinical significance of syndecan-1 expression in 116 squamous cell lung carcinomas treated with radical surgery. Paraffin-embedded tissue samples were immunostained with two antibodies against human syndecan-1 (B-B4 and 104-9). Syndecan-1 expression was higher in well differentiated cancers than in moderately or poorly differentiated cancers with tither antibody (P = 0.001 fur B-B4, and P < 0.0001 for 104-9). but no significant association was found with the primary tumour size (T-stage) or the clinical stage. When the median expression (10% of cancer cells positive in B-B4 staining) was used as the cut-off value. cancers with high expression were associated with more Favourable survival than those with low expression (the 2-year survival rate corrected for intercurrent deaths 84% vs 61%. P = 0.026). However, syndecan-1 expression was not an independent prognostic factor in a multivariate survival analysis. We conclude that syndecan-1 expression decreases in parallel with histological dedifferentiation in squamous cell carcinoma of the lung, and that low syndecan-1 expression is associated with unfavourable outcome. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.