Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam Study
Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam Study
复制标题
DOI：
10.1136/ard.2006.053538
复制
发表时间：
2007-02-01
影响因子：
27.4
通讯作者：
Bierma-Zeinstra, S. M. A.
中科院分区：
文献类型：
--
作者：
Reijman, M.;Pols, H. A. P.;Bierma-Zeinstra, S. M. A.
目的：探讨身体质量指数（BMI）与放射性膝关节及放射性髋关节骨关节炎的发病率和进展的关系。设计：队列研究。设置：基于人口。参与者：根据基线和随访x线片的可用性，从鹿特丹研究中选择了3585名年龄在bb0 = 55岁的人。主要结局指标：膝关节或髋关节骨关节炎的发生率在随访时定义为最低2级，基线时定义为0级或1级。骨关节炎的进展被定义为关节间隙宽度的减少。方法：对基线和随访（平均随访6.6年）的膝关节和髋关节x线片进行评估。在基线时测量BMI。结果：基线时的高BMI （BMI为27 kg/m(2)）与膝关节骨关节炎的发生相关（优势比（OR） 3.3），但与髋关节骨关节炎的发生无关。高BMI也与膝关节骨性关节炎的进展相关（OR 3.2）。对于髋关节，骨关节炎的进展和BMI之间没有明显的联系。结论：基于这些结果，我们得出BMI与膝关节骨关节炎的发病率和进展相关的结论。此外，BMI似乎与髋关节骨关节炎的发病率和进展无关。
Objective: To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis.Design: Cohort study.Setting: Population based.Participants: 3585 people aged >= 55 years were selected from the Rotterdam Study, on the basis of the availability of radiographs of baseline and follow-up.Main outcome measures: Incidence of knee or hip osteoarthritis was defined as minimally grade 2 at follow-up and grade 0 or 1 at baseline. The progression of osteoarthritis was defined as a decrease in joint space width.Methods: x Rays of the knee and hip at baseline and follow-up (mean follow-up of 6.6 years) were evaluated. BMI was measured at baseline.Results: A high BMI (> 27 kg/m(2)) at baseline was associated with incident knee osteoarthritis (odds ratio (OR) 3.3), but not with incident hip osteoarthritis. A high BMI was also associated with progression of knee osteoarthritis (OR 3.2). For the hip, a significant association between progression of osteoarthritis and BMI was not found.Conclusion: On the basis of these results, we conclude that BMI is associated with the incidence and progression of knee osteoarthritis. Furthermore, it seems that BMI is not associated with the incidence and progression of hip osteoarthritis.