Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance
Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance
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DOI：
10.1038/ismej.2014.239
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发表时间：
2015-07-01
期刊：
影响因子：
11
通讯作者：
Bosch, Thomas C. G.
中科院分区：
文献类型：
--
作者：
Fraune, Sebastian;Anton-Erxleben, Friederike;Bosch, Thomas C. G.
大多数动物的上皮表面被不同的微生物群落定植。虽然人们普遍认为共生细菌可以发挥有益的作用，但人们对其中的过程知之甚少。在这里，我们报道了在基础后生动物水螅中，外胚层上皮细胞被多层糖萼覆盖，为独特的微生物群落提供了栖息地。去除这种上皮微生物群会导致丝状真菌镰刀菌的致命感染。恢复细菌息肉中的复杂微生物群可以防止病原体感染。虽然与微生物群不同成员的单一关联不能提供充分的保护，但共生菌的加性和协同相互作用有助于充分的真菌抗性。我们的研究结果强调了常驻微生物群多样性作为防止病原体感染的保护因素的重要性。除了揭示共生菌在水螅体内的功能外，我们的研究结果还表明，共生菌之间的相互作用对抑制病原体感染至关重要。
Epithelial surfaces of most animals are colonized by diverse microbial communities. Although it is generally agreed that commensal bacteria can serve beneficial functions, the processes involved are poorly understood. Here we report that in the basal metazoan Hydra, ectodermal epithelial cells are covered with a multilayered glycocalyx that provides a habitat for a distinctive microbial community. Removing this epithelial microbiota results in lethal infection by the filamentous fungus Fusarium sp. Restoring the complex microbiota in gnotobiotic polyps prevents pathogen infection. Although mono-associations with distinct members of the microbiota fail to provide full protection, additive and synergistic interactions of commensal bacteria are contributing to full fungal resistance. Our results highlight the importance of resident microbiota diversity as a protective factor against pathogen infections. Besides revealing insights into the in vivo function of commensal microbes in Hydra, our findings indicate that interactions among commensal bacteria are essential to inhibit pathogen infection.