Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreas
Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreas
复制标题
与正常胰腺相比，慢性胰腺炎和胰腺腺癌中细胞外基质分子及其受体表达的改变
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
H. Beger
中科院分区：
文献类型：
--
作者：
S. Shimoyama;F. Gansauge;S. Gansauge;T. Oohara;H. Beger
摘要本研究的目的是阐明整合素和细胞外基质（ECM）分子在慢性胰腺炎（CP）和胰腺腺癌（PC）中与正常胰腺（NP）的表达和分布模式。免疫组织化学方法检测9个α-亚基（α2-α6、αv、αl、αm和αx）、4个β-亚基（β1、β3-β5）和4个ECM分子（IV型胶原、层粘连蛋白、纤维连接蛋白和玻璃体连接蛋白）的表达。在CP中，除αv外，所有整合素与NP的染色模式基本相同。CP部分腺泡细胞表达αv。PC组织中α2、α3、α6表达较强且呈弥漫性表达，α5未见表达。基底膜（BM）在CP中显示连续染色，而在PC中显示不连续或缺失染色，其中有IV型胶原、层粘连蛋白和玻璃体粘连蛋白抗体。部分癌细胞α2、α3、α6表达与IV型胶原、层粘连蛋白表达呈负相关。纤维连接蛋白在CP和PC中呈弥漫性间质表达。肝癌细胞中部分腺泡细胞或导管细胞表达VN。这些结果表明这些整合素和ECM分子参与了胰腺的炎症和恶性过程。
SummaryThe aim of this study was to elucidate the expression and distribution patterns of both integrins and extracellular matrix (ECM) molecules in chronic pancreatitis (CP) and pancreatic adenocarcinoma (PC) compared with normal pancreas (NP). Expression of nine α-subunits (α2-α6, αv, αl, αm, and αx), four β-subunits (β1, β3-β5), and four ECM molecules (type IV collagen, laminin, fibronectin, and vitronectin) was investigated immunohistochemically. In CP, all integrins except αv showed nearly the same staining patterns compared with NP. Some acinar cells in CP expressed αv. Whereas α2, α3, and α6 expression was stronger and diffuse, no α5 expression was seen in PC. Basement membrane (BM) showed continuous staining in CP, whereas it showed discontinuous/absent staining in PC with antitype IV collagen, laminin, and vitronectin antibodies. Some carcinoma cells showed reverse correlation between α2, α3, and α6 expression and type IV collagen and laminin expression. Fibronectin showed diffuse stromal expression in CP and PC. Some acinar cells or duct cells in CP carcinoma cells in PC showed intracellular VN expression. These results suggest that these integrins and ECM molecules are involved in inflammatory and malignant processes in pancreas.
登录
查看更多内容
正常和转化的培养人类细胞中纤连蛋白受体的生物合成和定位的差异。
影响因子：
11.2
作者：
Akiyama,SK;Larjava,H;Yamada,KM
通讯作者：
Yamada,KM
影响因子：
11.2
作者：
C. Waes;K. Kozarsky;A. Warren;L. Kidd;D. Paugh;Monica Lieber;T. Carey
通讯作者：
C. Waes;K. Kozarsky;A. Warren;L. Kidd;D. Paugh;Monica Lieber;T. Carey
纤连蛋白受体缺陷的中国仓鼠卵巢细胞变体的致瘤性增加。
影响因子：
11.2
作者：
Schreiner,C;Fisher,M;Hussein,S;Juliano,RL
通讯作者：
Juliano,RL
影响因子：
15.9
作者：
FELDINGHABERMANN, B;MUELLER, BM;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
11.2
作者：
L. Feldman;K. Shin;R. Natale;R. Todd
通讯作者：
L. Feldman;K. Shin;R. Natale;R. Todd