Evidence for both luminal and systemic factors in the control of rat intestinal epithelial replacement.
Evidence for both luminal and systemic factors in the control of rat intestinal epithelial replacement.
复制标题
控制大鼠肠上皮替代的管腔和全身因素的证据。
DOI：
10.1042/cs0500139
复制
发表时间：
1976
期刊：
影响因子：
6
通讯作者：
R. Clarke
中科院分区：
文献类型：
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作者：
R. Clarke
1.体内分离大鼠小肠自排空囊可使Lieberkuhn隐窝的细胞产量减半，秋水仙碱阻断法测得。2.隔离肠囊大鼠饥饿48h后，囊内细胞生成率进一步减半。3.将蒸馏水注入离体肠囊72小时，对饥饿和喂食大鼠的肠囊细胞产量有相似的刺激作用，提示饥饿大鼠的细胞产量下降不是由于细胞合成所需物质的缺乏所致。4.讨论了肠道神经支配和全身激素影响在肠上皮替代中的可能作用。
1. Isolation of a self-emptying sac of rat small intestine in vivo halved the cell production rate in the crypts of Lieberkuhn as measured by colchicine blockade. 2. Starvation for 48 h of rats with isolated intestinal sacs caused a further halving of cell production rate in the sac. 3. Infusion of distilled water into isolated intestinal sacs for 72 h caused a similar degree of stimulation of cell production in sacs in fed and starved rats, suggesting that the fall in cell production rate on starving a rat bearing an isolated sac is not due to the non-availability of the substances required for cell synthesis. 4. The possible contribution of innervation of the gut, and of systemic hormonal influences, on intestinal epithelial replacement is discussed.